PMID: 9533419Apr 9, 1998Paper

Sympathetic functions in NG-nitro-L-arginine-methyl-ester-induced hypertension: modulation by the renin-angiotensin system

Journal of Hypertension
A K-LaflammeJ de Champlain

Abstract

Nitric oxide and angiotensin II have been shown to attenuate cardiac beta-adrenergic inotropism. To study sympathetic presynaptic and post-synaptic functions after chronic nitric oxide synthesis blockade with NG-nitro-L-arginine-methyl-ester (L-NAME, for 40 days) in association with renin-angiotensin system blockade (during the last 12 days) in order to evaluate the possible physiological interactions between these systems. Haemodynamic parameters in conscious rats were assessed. Release of noradrenaline from isolated atria and cardiac beta-adrenergic-adenylyl cyclase pathway in rats of sham-treated and L-NAME-treated groups, with or without losartan or enalaprilat treatment, were assessed. L-NAME-treated rats developed a time-dependent increase in blood pressure associated with increased plasma adrenaline levels whereas plasma noradrenaline and cardiac catecholamine levels were similar to those in sham-treated rats. Field-stimulated release of noradrenaline, cardiac beta-adrenoceptor density and affinity and isoproterenol-stimulated formation of cyclic AMP were similar in sham and L-NAME-treated rats. However, Gpp(NH)p, NaF and forskolin-stimulated adenylyl cyclase activity were greater in L-NAME rats although Gs and Gi protei...Continue Reading

References

Sep 1, 1978·The American Journal of Physiology·K M BaldwinR E Lewis
Apr 1, 1992·Cardiovascular Research·A H HendersonJ A Smith
Jan 1, 1992·Journal of Cardiovascular Pharmacology·P R Saxena
Jan 1, 1991·Journal of Molecular and Cellular Cardiology·A M ShahA H Henderson
Aug 1, 1991·The Journal of Physiology·J A SmithM J Lewis
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D D ReesS Moncada
Aug 15, 1989·Biochemical and Biophysical Research Communications·J F Coquil, G Brunelle
Jan 1, 1989·Clinical and Experimental Hypertension. Part A, Theory and Practice·W LinzD Ganten
Jul 1, 1995·The Journal of General Physiology·X HanW R Giles
Jan 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J L BalligandT Michel
Mar 1, 1996·Hypertension·H Gomez LlambiC M Taquini
May 28, 1996·Proceedings of the National Academy of Sciences of the United States of America·W L GrossR A Kelly
Mar 15, 1996·Circulation·P MohanS U Sys
Apr 1, 1996·Journal of Molecular and Cellular Cardiology·U IkedaK Shimada
Jul 1, 1996·The American Journal of Physiology·C V OddisM S Finkel
Feb 18, 1997·Circulation·R A Kelly, T W Smith

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Citations

Mar 30, 2005·Autonomic Neuroscience : Basic & Clinical·Rong MaWei Wang
Mar 18, 2004·Antioxidants & Redox Signaling·Madhu B Anand-Srivastava, Francesco Di Fusco
Jan 23, 1999·Current Opinion in Nephrology and Hypertension·M Sander, R G Victor
Apr 28, 2005·Clinical and Experimental Pharmacology & Physiology·Rohit RamchandraSimon C Malpas
Jun 14, 2005·European Journal of Clinical Investigation·F SimkoI Bernatova
Dec 7, 2002·Stroke; a Journal of Cerebral Circulation·Delphine LamireauSylvain Chemtob
Mar 7, 2001·Hypertension·A D DobrianR L Prewitt
Jun 16, 2006·Journal of Cardiovascular Pharmacology·Shinji SetoKatsusuke Yano
Nov 18, 1998·Current Opinion in Nephrology and Hypertension·S Klahr
Mar 15, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sharyn M Fitzgerald, Michael W Brands
Sep 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Rebecca W CarterNancy L Kanagy
Mar 25, 2009·Pharmacology & Therapeutics·Emily J Tsai, David A Kass

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