Sympathetic ingrowth to the trigeminal ganglion following intracerebroventricular infusion of nerve growth factor

Brain Research
S E ShoemakerL G Isaacson

Abstract

The objective of the present study was to examine the remodeling of uninjured sympathetic axons in the adult rat trigeminal ganglion following a 2-week in vivo intracerebroventricular infusion of NGF. The accumulation of infused NGF in the trigeminal was assessed using ELISA and sympathetic fibers were localized immunohistochemically with an antibody to tyrosine hydroxylase (TH). In addition, high performance liquid chromatography coupled with electrochemical detection (HPLC-ECD) allowed for biochemical measurements of the catecholamines norepinephrine (NE) and dopamine (DA). Increased NGF protein in the trigeminal ganglion was paralleled by a significant increase in sympathetic fibers and pericellular plexuses (i.e. baskets) in the cell body regions. Some ganglia showed elevated NE following NGF infusion, yet the 88% increase in mean NE did not reach significance. Following bilateral removal of the sympathetic superior cervical ganglia (SCG), a significant reduction was observed in overall NE levels and in TH-immunoreactive (-ir) fibers in the cell body regions and peripheral branches, suggesting the SCG as the origin of the sympathetic ingrowth. However, mean DA levels as well as TH-ir fibers within the trigeminal central bra...Continue Reading

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Citations

Feb 5, 2005·Plastic and Reconstructive Surgery·Michael P McConnellGregory R D Evans
Mar 3, 2007·Brain Research·Chris L RandolphLori G Isaacson
Aug 18, 2020·Journal of Pain Research·Lijia MaiWenguo Fan

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