PMID: 45305Apr 30, 1979

Sympathetic mediation of induced and spontaneous activity of the pelvis-ureter in vitro

Bollettino della Società italiana di biologia sperimentale
D Mitolo-Chieppa, F Cagnazzo


The spontaneous activity of guinea-pig renal pelvis-ureter is regulated by the adrenergic system. Spontaneous rhythmic contractions, and contractions induced by Noradrenaline are inhibited by Dihidroergotamine and Phentolamine. Alpha-adrenergic blocking agents block also contractions induced by histamine, angiotensin and barium chloride, but not contractions induced by electric stimulation. The Authors suggest an hypothetical model for the activation of the adrenergic receptor: Noradrenaline (NE) recognition sites are activated only by NE, whereas complementary sites can be activated by NE or other agonists. Both sites are blocked by alpha-adrenergic blocking agents.

Related Concepts

Barium chloride, octaammoniate
Adrenergic alpha-Antagonists
Angiotensin II, Val(5)-
Chloride Ion Level
Ergotam von ct
Electric Stimulation Technique
Cavia porcellus
Renal Pelvis

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