Sympathetic modulation of activity in Adelta- and C-primary nociceptive afferents after intradermal injection of capsaicin in rats

Journal of Neurophysiology
Yong RenQing Lin

Abstract

Neuropathic and inflammatory pain can be modulated by the sympathetic nervous system. In some pain models, sympathetic postganglionic efferents are involved in the modulation of nociceptive transmission in the periphery. The purpose of this study is to examine the sensitization of Adelta- and C-primary afferent nociceptors induced by intradermal injection of capsaicin (CAP) to see whether the presence of sympathetic efferents is essential for the sensitization. Single primary afferent discharges were recorded from the tibial nerve after the fiber types were identified by conduction velocity in anesthetized rats. An enhanced response of some Adelta- and most C-primary afferent fibers to mechanical stimuli was seen in sham-sympathectomized rats after CAP (1%, 15 mul) injection, but the enhanced responses of both Adelta- and C-fibers were reduced after sympathetic postganglionic efferents were removed. Peripheral pretreatment with norepinephrine by intraarterial injection could restore and prolong the CAP-induced enhancement of responses under sympathectomized conditions. In sympathetically intact rats, pretreatment with an alpha(1)-adrenergic receptor antagonist (terazosin) blocked completely the enhanced responses of C-fibers af...Continue Reading

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Citations

Jun 26, 2007·European Journal of Pain : EJP·Peter D Drummond
Jul 10, 2010·Journal of Korean Neurosurgical Society·Chan Hong ParkSang Ho Lee
Jun 6, 2008·European Journal of Pain : EJP·Peter D Drummond
Nov 17, 2009·Journal of the Peripheral Nervous System : JPNS·Anette T MøllerTroels Staehelin Jensen
May 21, 2011·Clinical and Experimental Pharmacology & Physiology·Jun WangYan Zhao
Jan 27, 2019·Experimental and Therapeutic Medicine·Ovidiu GrigoreConstantin Caruntu
Sep 29, 2017·Frontiers in Neurology·Jason J Ivanusic
Oct 4, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Jeffrey L Krajewski
Oct 13, 2006·Progress in Neurobiology·Antti Pertovaara
May 22, 2007·The Journal of Pain : Official Journal of the American Pain Society·Jason G MeisnerJana Sawynok

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