Sympathetic nerve biology in essential hypertension

Clinical and Experimental Pharmacology & Physiology
M D EslerGavin Lambert

Abstract

1. Although the importance of sympathetic nervous activation in the pathogenesis of essential hypertension is well documented, the exact pathophysiology of the sympathetic nervous dysfunction present remains to be delineated. There are several possible explanations for the increased spillover of noradrenaline from the kidneys and heart to plasma, a key piece of evidence supporting the neurogenic basis of essential hypertension, in addition to the obvious one of an increased rate of sympathetic nerve firing. 2. The possibility that there may be an increase in the density of sympathetic innervation in human hypertension, well documented in the spontaneously hypertensive rat, is currently under investigation by us. 3. Adrenaline cotransmission is present in the cardiac sympathetic nerves of patients with essential hypertension, presumptive evidence of their exposure to high levels of stress and a possible basis for the observed increase in cardiac noradrenaline spillover, through presynaptic augmentation of noradrenaline release. 4. Phenotypic evidence exists also of faulty noradrenaline reuptake into the sympathetic nerves of the heart in essential hypertension, an abnormality that would amplify the sympathetic neural signal by i...Continue Reading

References

Jan 1, 1992·Hypertension·J S Floras
Sep 1, 1991·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·I T MeredithG Eisenhofer
Dec 15, 1994·The Journal of Physiology·V G MacefieldA B Vallbo
Mar 6, 1997·The New England Journal of Medicine·D S GoldsteinI J Kopin
Nov 4, 2000·The Journal of Physiology·D R Seals, M D Esler

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Citations

Feb 5, 2008·International Urology and Nephrology·H Nandeesha
May 2, 2003·Current Hypertension Reports·Alan F SvedJudith C Sved
May 22, 2003·Psychiatry Research·Nick J CouplandDavid J Nutt
Jul 2, 2003·Brain, Behavior, and Immunity·Paul J MillsMichael G Ziegler
Jul 30, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kensaku AiharaMichiaki Mishima
Feb 21, 2006·Clinical and Experimental Pharmacology & Physiology·Ying-Xin PengMin Wu
May 4, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Domitila A Huber, Ann M Schreihofer
Mar 23, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Bruce D CarterNazareno Paolocci
Apr 2, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Patrick J Mueller
Mar 12, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·François M Abboud
Oct 8, 2011·Journal of Applied Physiology·Nicholas A Mischel, Patrick J Mueller
Aug 4, 2010·The Journal of Clinical Investigation·Ilka MatharMarc Freichel
Mar 14, 2014·Current Atherosclerosis Reports·William H Frishman, Daniel Glicklich
Jun 2, 2011·International Journal of Hypertension·Vasilios PapademetriouKonstantinos Tsioufis
Jun 13, 2012·The Journal of Physiology·Ana P AbdalaJulian F R Paton
Feb 16, 2010·The American Journal of Cardiology·Michael DoumasVasilios Papademetriou
Jan 8, 2010·Autonomic Neuroscience : Basic & Clinical·Melissa LiGregory Fink
Jul 1, 2008·Neuroscience and Biobehavioral Reviews·Julian F R Paton, Hidefumi Waki
May 29, 2013·Clinical and Experimental Pharmacology & Physiology·Kathleen V BarrettIris Z Jaffe
Aug 8, 2006·The Journal of Urology·Charlotte Graugaard-JensenJens Christian Djurhuus
Sep 21, 2005·Autonomic Neuroscience : Basic & Clinical·Ljubica GavrilovicSladjana Dronjak
Sep 13, 2005·Pharmacology & Therapeutics·Francisco J López-Hernández, José M López-Novoa
Oct 1, 2013·Autonomic Neuroscience : Basic & Clinical·Erica A WehrweinDavid L Kreulen
May 18, 2010·International Journal of Cardiology·Dogan ErdoganMehmet Ozaydin
May 5, 2009·NeuroImage·J Richard Jennings, Ydwine Zanstra
Mar 19, 2014·Autonomic Neuroscience : Basic & Clinical·Erica A WehrweinJohn W Osborn
Mar 19, 2016·Experimental Physiology·Nephtali MarinaAlexander V Gourine
May 29, 2007·American Journal of Hypertension·Raphael R de A FreitasMiriam S Dolnikoff
Sep 12, 2016·Revista Portuguesa De Cardiologia : Orgão Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology·Ahmad Al-FakhouriRami N Khouzam
Apr 10, 2010·American Journal of Hypertension·Pamela J DavernGeoffrey A Head
Dec 24, 2017·Glia·Nephtali MarinaAlexander V Gourine

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