PMID: 11334845May 4, 2001Paper

Sympathetic nerve sprouting, electrical remodeling and the mechanisms of sudden cardiac death

Cardiovascular Research
P S ChenM C Fishbein

Abstract

The purpose of this article is to review the nerve sprouting hypothesis of sudden cardiac death. It is known that sympathetic stimulation is important in the generation of sudden cardiac death. For example, there is a diurnal variation of sudden death rate in patients with myocardial infarction. Beta blockers, or drugs with beta blocking effects, are known to prevent sudden cardiac death. It was unclear if the cardiac nerves in the heart play only a passive role in the mechanisms of sudden death. To determine if nerve sprouting and neural remodeling occur after myocardial infarction, we performed immunocytochemical studies of cardiac nerves in explanted native hearts of transplant recipients. We found that there was a positive correlation between nerve density and a clinical history of ventricular arrhythmia. Encouraged by these results, we performed a study in dogs to determine whether or not nerve growth factor (NGF) infusion to the left stellate ganglion can facilitate the development of ventricular tachycardia (VT), ventricular fibrillation (VF), and sudden cardiac death (SCD). The results showed that augmented myocardial sympathetic nerve sprouting through NGF infusion plus atrioventricular (AV) block and MI result in a 44...Continue Reading

Citations

May 5, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Riikka LautamäkiFrank M Bengel
Feb 16, 2006·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Stephen Oppenheimer
Apr 26, 2008·Heart Failure Reviews·Dawood Darbar
Jul 10, 2003·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Kelley P Anderson
Dec 23, 2003·Current Opinion in Cardiology·Richard L Verrier, Charles Antzelevitch
Oct 30, 2009·Current Opinion in Cardiology·Rachel Lampert
Jan 15, 2005·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Richard L VerrierKevin F Kwaku
Feb 25, 2006·Acta Physiologica·K B AnderssonG Christensen
Jun 15, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Norman C WangJeffrey J Goldberger
Jan 24, 2012·American Journal of Physiology. Heart and Circulatory Physiology·K NairK Nanthakumar
Dec 18, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Olujimi A AjijolaKalyanam Shivkumar
Nov 6, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Stanley F FernandezJames A Fallavollita
Mar 17, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Heidi L LujanStephen E Dicarlo
Jul 30, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Heidi L LujanStephen E DiCarlo
Apr 28, 2012·Circulation Research·Rachel C MylesCrystal M Ripplinger
Nov 14, 2013·Autonomic Neuroscience : Basic & Clinical·Jean C HardwickE Marie Southerland
May 14, 2014·Annual Review of Biophysics·Liang Han, Xinzhong Dong
Aug 5, 2014·Internal Medicine·Hideki Hayashi, Tamiro Kawaguchi
Dec 3, 2013·Heart Failure Reviews·Emilia D'EliaEmilio Vanoli
Jun 14, 2013·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Christian UkenaHans-Ruprecht Neuberger
Jan 29, 2016·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Vineet Kumar, Arka Chaterjee
Apr 24, 2013·The Journal of Surgical Research·Lacee J LaufenbergVictor Ruiz-Velasco
Jan 19, 2016·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Saurabh Malhotra, John M Canty
Apr 3, 2010·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Huazhi WenCongxin Huang
Feb 5, 2010·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Masamichi Hirose
Sep 15, 2009·Autonomic Neuroscience : Basic & Clinical·Jason A Luther, Susan J Birren
Aug 6, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Masahiro OgawaPeng-Sheng Chen
Dec 17, 2015·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Mischa T RijniersePaul Knaapen
Jan 6, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Edward J Ciaccio
Jan 6, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Yen-Bin LiuPeng-Sheng Chen
Dec 19, 2006·Journal of Cardiac Failure·Philip B Adamson, Edward M Gilbert
Oct 4, 2015·International Journal of Cardiology·Wenfang Xia, Yu Liu
Dec 22, 2004·Journal of Cardiovascular Electrophysiology·Kalyanam Shivkumar, James N Weiss
Jun 27, 2007·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Gregory EngelVictor F Froelicher

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Remodeling

Cardiac remodeling in response to a myocardial infarction is characterized by progressive ventricular dilatation, cardiac hypertrophy, fibrosis, and deterioration of cardiac performance. Discover the latest research on Cardiac Remodeling here.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.