PMID: 81987Nov 4, 1978Paper

Sympathetic nervous system and blood-pressure control in essential hypertension

Lancet
T PhilippU Cordes

Abstract

In normotensive subjects an inverse correlation was observed between an index of sympathetic nervous activity (the plasma-noradrenaline concentration during physical exercise) and reactivity to exogenous noradrenaline. This relationship was invariably disturbed in age-matched patients with essential hypertension. Multiple-regression analysis revealed a highly significant correlation between the combination of both factors and the height of mean arterial blood-pressure (r=0.91). The findings suggest that sympathetic nervous activity and pressor response to noradrenaline together form an important determinant of the arterial blood-pressure level. An inverse relationship could be demonstrated between plasma-renin concentration and pressor response to angiotensin II in normotensives, and this relationship was unchanged in hypertensive patients. Therefore angiotensin II does not appear to contribute directly to high blood-pressure.

Citations

Mar 1, 1990·Clinical Cardiology·M LehmannA Schmid
Jan 1, 1982·European Journal of Clinical Pharmacology·J W HenquetK H Rahn
Mar 1, 1994·Cardiovascular Drugs and Therapy·S Julius
Nov 3, 1980·Klinische Wochenschrift·M GrimmZ Glück
Oct 1, 1979·Klinische Wochenschrift·A HeidlandG Schmid
Sep 1, 1991·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·J S KoonerC J Mathias
Sep 1, 1991·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·M LiguerosM Wilkins
May 1, 1981·Basic Research in Cardiology·B Grubeck-LoebensteinW Waldhäusl
Jan 1, 1986·International Urology and Nephrology·M Yoshikawa, T Nakada
Sep 12, 2000·Current Hypertension Reports·S D Nesbitt, S Julius
Sep 12, 2000·Current Hypertension Reports·J L Izzo, A A Taylor
Apr 1, 1982·General Hospital Psychiatry·J W Lehmann, H Benson
Nov 14, 1981·Lancet·M J Brown, I Macquin
Jan 12, 2001·Journal of the American College of Cardiology·O OldenburgA Kribben
Aug 21, 1980·The New England Journal of Medicine·P E Cryer
Apr 1, 2006·Simulation in Healthcare : Journal of the Society for Simulation in Healthcare·C Daniel BensonGary E Loyd
Oct 1, 1981·British Heart Journal·M GrimmC Beretta-Piccoli
Sep 1, 1987·The Journal of Clinical Investigation·B EganS Julius
Apr 20, 2004·British Journal of Clinical Pharmacology·René R WenzelRafael F Schäfers
Jan 1, 1989·Clinical and Experimental Hypertension. Part A, Theory and Practice·Y ItoT Fujita
Apr 1, 1996·Clinical and Experimental Hypertension : CHE·S Julius
Jan 1, 1983·Current Medical Research and Opinion·M GrimmC Beretta-Piccoli
Apr 1, 1993·Journal of Autonomic Pharmacology·J Marín
May 1, 1997·Clinical and Experimental Hypertension : CHE·S H TamJ A Whitworth
Jan 1, 1989·Clinical and Experimental Hypertension. Part A, Theory and Practice·G YiJ Fan
Jan 1, 1989·Clinical and Experimental Hypertension. Part A, Theory and Practice·P Weidmann
Jan 1, 1989·Clinical and Experimental Hypertension. Part A, Theory and Practice·J de ChamplainR A Nadeau
Jun 1, 1985·British Journal of Obstetrics and Gynaecology·P G WhittakerT Lind
Jan 1, 1987·Kidney International·K Laederach, P Weidmann
Jan 1, 1981·International Journal of Health Services : Planning, Administration, Evaluation·R CooperA Schatzkin

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