Sympathetic Nervous System Control of Carbon Tetrachloride-Induced Oxidative Stress in Liver through α-Adrenergic Signaling

Oxidative Medicine and Cellular Longevity
Jung-Chun LinHerng-Sheng Lee

Abstract

In addition to being the primary organ involved in redox cycling, the liver is one of the most highly innervated tissues in mammals. The interaction between hepatocytes and sympathetic, parasympathetic, and peptidergic nerve fibers through a variety of neurotransmitters and signaling pathways is recognized as being important in the regulation of hepatocyte function, liver regeneration, and hepatic fibrosis. However, less is known regarding the role of the sympathetic nervous system (SNS) in modulating the hepatic response to oxidative stress. Our aim was to investigate the role of the SNS in healthy and oxidatively stressed liver parenchyma. Mice treated with 6-hydroxydopamine hydrobromide were used to realize chemical sympathectomy. Carbon tetrachloride (CCl4) injection was used to induce oxidative liver injury. Sympathectomized animals were protected from CCl4 induced hepatic lipid peroxidation-mediated cytotoxicity and genotoxicity as assessed by 4-hydroxy-2-nonenal levels, morphological features of cell damage, and DNA oxidative damage. Furthermore, sympathectomy modulated hepatic inflammatory response induced by CCl4-mediated lipid peroxidation. CCl4 induced lipid peroxidation and hepatotoxicity were suppressed by administ...Continue Reading

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Citations

Jul 14, 2016·Biological Trace Element Research·Jennifer Beatriz Silva MoraisDilina do Nascimento Marreiro
Jun 18, 2019·Oxidative Medicine and Cellular Longevity·Qianqian ZhangHong Jiang
Nov 29, 2016·Oxidative Medicine and Cellular Longevity·Ruibing FengJian-Bo Wan
May 2, 2021·Journal of Ethnopharmacology·Gustavo Duarte Bocayuva TavaresCésar Luis Siqueira Júnior

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Methods Mentioned

BETA
deamination
Assay
enzyme-linked immunosorbent assay
transmission electron microscopy
ELISA
Antibody
Antibody Array

Software Mentioned

TotalLab Quant
ImageJ

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