Sympathetic nervous system control of vascular function and blood pressure during pregnancy and preeclampsia

Journal of Hypertension
Frank T Spradley

Abstract

: Proper vascular tone and blood pressure regulation during pregnancy are important for immediate and long-term cardiovascular health of the mother and her offspring. Preeclampsia is clinically defined as new-onset maternal hypertension accompanied by cardiovascular, renal, and/or neural abnormalities presenting in the second half of pregnancy. There is strong evidence to support that preeclampsia is mediated by attenuations in uteroplacental vascular remodeling and increases in vasoconstriction with subsequent placental ischemia/reperfusion-induced release of hypertensive substances into the maternal circulation. These include antiangiogenic and pro-inflammatory factors. There is also evidence implicating increased sympathetic nervous system activity (SNA) in this maternal disorder, but this mostly includes data correlating severity of disease with catecholamine levels and elevated muscle SNA. These measurements have not confirmed a causative role for SNA in the pathogenesis of preeclampsia. Therefore, studies are needed to provide a comprehensive understanding of SNA and its control of vascular function and blood pressure regulation during normal pregnancy in order to set the stage for exploring the mechanisms mediating the e...Continue Reading

References

Jan 1, 1977·Acta Obstetricia Et Gynecologica Scandinavica·F P Zuspan
Dec 1, 1992·American Journal of Obstetrics and Gynecology·D Yang, K E Clark
Dec 1, 1992·American Journal of Obstetrics and Gynecology·S T Davidge, M K McLaughlin
Mar 31, 1989·Biochemical and Biophysical Research Communications·Y TabuchiT Ogihara
Jun 15, 1989·Biochemical and Biophysical Research Communications·Y TabuchiT Ogihara
Oct 1, 1987·Biology of Reproduction·B G SteinetzG Lust
May 1, 1985·European Journal of Obstetrics, Gynecology, and Reproductive Biology·K E AiraksinenJ T Takkunen
Oct 1, 1995·American Journal of Obstetrics and Gynecology·C M SalafiaA M Vintzileos
Jul 1, 1994·Journal of the Autonomic Nervous System·M KobayashiS Nosaka
Dec 1, 1993·American Journal of Obstetrics and Gynecology·M C MeyerM K McLaughlin
May 1, 1993·Journal of Applied Physiology·R T Dowell, C D Kauer
Jul 1, 1996·Obstetrics and Gynecology·P G WhittakerT Lind
Nov 14, 1996·The New England Journal of Medicine·H P SchobelR E Schmieder
Apr 1, 1997·American Journal of Obstetrics and Gynecology·Y NiG Osol
Oct 23, 1997·Journal of the Autonomic Nervous System·G VaccaN Surico
May 18, 1999·American Journal of Obstetrics and Gynecology·M G ZlatnikR E Garfield
May 20, 1999·The Journal of Physiology·W H CookeD L Eckberg
Sep 2, 1999·European Journal of Obstetrics, Gynecology, and Reproductive Biology·S KhatunT Terao
Apr 6, 2000·American Journal of Physiology. Heart and Circulatory Physiology·C C YangH I Chen
Apr 14, 2000·American Journal of Obstetrics and Gynecology·S KhatunT Terao
May 4, 2000·British Journal of Anaesthesia·C D KuoY S Tsai
Oct 20, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·S R AbramJ P Granger
Apr 26, 2002·Anesthesia and Analgesia·Steven Y WangScott Segal
Feb 27, 2003·Biology of Reproduction·Christy-Lynn M Cooke, Sandra T Davidge
Jul 19, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kathleen P O'Hagan, Jennifer A Alberts
Nov 1, 1957·American Journal of Obstetrics and Gynecology·W RAAB
Aug 1, 1962·American Journal of Obstetrics and Gynecology·L A CIBILSF P ZUSPAN
Apr 5, 2005·Clinical Obstetrics and Gynecology·Richard J Levine, S Ananth Karumanchi
Sep 24, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yanny E LauGregory D Fink
Feb 3, 2006·Reproduction : the Official Journal of the Society for the Study of Fertility·Jean St-LouisMichèle Brochu
Feb 14, 2006·The Journal of Physiology·Lawrence P ReynoldsThomas E Spencer
Oct 3, 2006·Lancet·Carine RonsmansUNKNOWN Lancet Maternal Survival Series steering group

❮ Previous
Next ❯

Citations

Jun 4, 2019·Journal of Hypertension·Martin R SalazarHoracio A Carbajal
Jun 30, 2019·International Journal of Molecular Sciences·Helmut K LacknerManfred G Moertl
Aug 27, 2019·Frontiers in Neurology·Dalia YousifTimo Siepmann
Sep 26, 2019·Frontiers in Endocrinology·Eugenie R LumbersKirsty G Pringle
Apr 23, 2020·Journal of Family Medicine and Primary Care·Jayesh D SolankiKokila Hiren Desai
Oct 3, 2020·Journal of the American College of Cardiology·Christopher W IvesSuzanne Oparil
May 4, 2021·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Nevin TütenEduard Malik
Jul 27, 2021·Hormones : International Journal of Endocrinology and Metabolism·Marieta P TheodorakopoulouKonstantina Dipla

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.