Sympathetic nervous system influences salt appetite in four strains of rats

Physiology & Behavior
N BourjeiliD L Ely

Abstract

Sodium appetite and preference were examined in four rat strains using a social stressor and drugs to block sympathetic nervous system (SNS) activity. We have studied these strains for over 14 yr in our laboratory and the SHR strain has increased blood pressure and increased sympathetic nerve activity. The F1 crosses produce male offspring with the Y chromosome from a hypertensive or normotensive father, to examine its influence on sodium appetite. The pharmacological manipulation produces blockage of the SNS which may be partially responsible for stress induced sodium appetite. The objectives were to determine: (i) if the SNS was necessary for stress induced increased salt appetite; and (ii) if the Y chromosome from a hypertensive father increased salt intake or preference. Four strains (n = 6-8/group) of male rats were studied from 3-6 mo of age: normotensive Wistar-Kyoto (WKY) rats, spontaneously hypertensive rats (SHR) and hybrid crosses between a WKY mother and SHR father (WS) and the reciprocal cross (SW). Each group consumed Purina rat chow (0.3% Na) and was given a four-bottle choice of salt water ad lib (0.0%, 0.5%, 1.0%, and 1.5% NaCl). Social stress produced by intruder males significantly increased salt intake in al...Continue Reading

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Citations

Dec 4, 2003·Brain Research·Lisandra Brandino de OliveiraJosé Vanderlei Menani
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