Sympathetic neural responses to smoking are age dependent

Journal of Hypertension
Dagmara HeringKrzysztof Narkiewicz

Abstract

Smoking is an important risk factor for cardiovascular disease. Sympathetic responses to cigarette smoking may be implicated in the link between smoking and cardiovascular disease. We tested the hypothesis that the sympathetic neural responses to smoking are age dependent. We examined the effects of cigarette smoking and sham smoking on muscle sympathetic nerve activity, blood pressure and heart rate in 14 normotensive middle-aged (49 +/- 4 years) and 12 young (29 +/- 4 years) habitual smokers matched for body mass index (25 +/- 2 kg/m2 in both groups). Sham smoking had no significant effect on sympathetic drive, blood pressure or heart rate in either group. Cigarette smoking increased heart rate in both middle-aged subjects and young subjects. In comparison to younger subjects, middle-aged smokers showed similar smoking-related increases in systolic blood pressure (SBP) [10 +/- 3 versus 12 +/- 2 mmHg, respectively, not significant (NS)]. Smoking decreased sympathetic nerve activity by 28 +/- 12% of baseline values (P < 0.01) in young subjects. However, muscle sympathetic nerve activity did not change significantly after smoking in middle-aged subjects (5 +/- 8%, NS), despite the increased blood pressures, which would be expect...Continue Reading

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Citations

May 13, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Sung Hun KimHee-Kwon Park
Mar 19, 2014·Microvascular Research·M RossiL Carrozzi
Oct 7, 2009·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Goksel CagirciRamazan Akdemir
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Feb 4, 2016·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M S BianchimV Z Dourado
May 16, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jian CuiLawrence I Sinoway
Mar 29, 2020·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Phoebe D GarciaHolly R Middlekauff
May 1, 2010·Blood Pressure·Dagmara HeringKrzysztof Narkiewicz

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