PMID: 6164438Apr 6, 1981Paper

Sympathetic noradrenergic sprouting in response to central cholinergic denervation; a histochemical study of neuronal sprouting in the rat hippocampal formation

Brain Research
K A CrutcherJ N Davis

Abstract

An unusual example of neuronal sprouting occurs in the rat brain. Several weeks after fimbrial transection or septal lesions, peripheral sympathetic fibers appear in the dentate and hippocampal gyri. We compared the distribution of normal cholinergic septohippocampal fibers and nerve terminals with the distribution of noradrenergic sympathetic (sympathohippocampal) fibers after septal lesions using anterograde transport of horseradish peroxidase and fluorescence histochemistry. In addition, we destroyed other afferents to the hippocampal formation and examined the effect of subtotal septal lesions on acetylcholinesterase staining and the distribution of sympathohippocampal fibers. The combined results of these experiments suggest that peripheral noradrenergic fibers sprout specifically in response to destruction of central cholinergic fibers after septal lesions. This appears to be the first model of neuronal sprouting in the central nervous system where one identified transmitter system (noradrenergic) sprouts only in response to, and perhaps to replace, another specific transmitter system (cholinergic).

References

Nov 15, 1975·The Journal of Comparative Neurology·R Y Moore, A E Halaris
Dec 1, 1979·Experimental Neurology·K A CrutcherJ N Davis
Feb 1, 1972·The Journal of Comparative Neurology·A Hjorth-Simonsen, B Jeune
Aug 23, 1974·Brain Research·K StöckelH Thoenen
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Jun 1, 1969·Brain Research·G Raisman
May 1, 1966·The Journal of Comparative Neurology·D C Goodman, J A Horel

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Citations

Jun 30, 1987·Brain Research·A M PalmerJ S Snowden
Jan 1, 1983·Brain Research Bulletin·M D Chafetz, F H Gage
Jan 1, 1987·Behavioral and Neural Biology·R P KesnerK A Crutcher
Jul 14, 1999·Neurochemistry International·M McLaughlinJ McCulloch
Mar 26, 2002·Autonomic Neuroscience : Basic & Clinical·Keith A Crutcher
Sep 28, 1998·The European Journal of Neuroscience·M D KawajaJ P Julien
Feb 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·S R WhittemoreH Persson
May 1, 1987·Neurobiology of Aging·R M Booze, J N Davis
Nov 1, 2008·The European Journal of Neuroscience·Vandana ZamanLawrence D Middaugh
Jun 27, 1983·Brain Research·R Madison, J N Davis
Aug 13, 1990·Brain Research·B N Saffran, K A Crutcher

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