Sympathetic overdrive in the metabolic syndrome: meta-analysis of published studies.

Journal of Hypertension
Fosca Quarti TrevanoGuido Grassi

Abstract

The microneurographic technique has shown that sympathetic overactivity may characterize patients with the metabolic syndrome. However, technical and methodological limitations of the studies prevented to draw definite conclusions. The present meta-analysis evaluated 16 microneurographic studies including 650 individuals, 444 metabolic syndrome patients and 206 healthy controls, respectively. The analysis was primarily based on muscle sympathetic nerve traffic (MSNA) quantified by microneurography in metabolic syndrome. Assessment was extended to the relationships of MSNA with an indirect neuroadrenergic marker, such as heart rate (HR), anthropometric variables, as BMI, waist-hip ratio and metabolic profile. Metabolic syndrome individuals displayed MSNA values (means ± SEM) significantly greater than controls (58.6 ± 4.8 versus 41.6 ± 4.1 bursts/100 heart beats, P < 0.01). This result was independent on the concomitant presence of sleep apnea and drug treatment. MSNA was directly and significantly related to clinic SBP (r = 0.91, P < 0.01) but not to BMI (r = 0.17, P = NS), whereas no significant relationship was found between MSNA and metabolic variables included in the definition of metabolic syndrome. No significant correlat...Continue Reading

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References

Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Dec 18, 1998·Journal of Hypertension·G GrassiG Mancia
Aug 25, 1999·Journal of Hypertension·G Grassi, M Esler
Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
Mar 1, 2003·Acta Physiologica Scandinavica·K Narkiewicz, V K Somers
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Dec 24, 2004·Diabetologia·R J HuggettD A S G Mary
Aug 11, 2005·The Journal of Clinical Endocrinology and Metabolism·Nora E StraznickyPaul J Nestel
Dec 6, 2008·The American Journal of Clinical Nutrition·Nora E StraznickyElisabeth A Lambert
Jun 12, 2009·Metabolism: Clinical and Experimental·Guido GrassiGiuseppe Mancia
Dec 29, 2012·The Journal of Clinical Endocrinology and Metabolism·Nora E StraznickyElisabeth A Lambert
Mar 25, 2014·Experimental Physiology·Jacqueline K LimbergWilliam G Schrage
Apr 1, 2014·Autonomic Neuroscience : Basic & Clinical·Jacqueline LimbergWilliam Schrage
Apr 16, 2014·The Lancet. Diabetes & Endocrinology·Markus SchlaichGavin Lambert
May 24, 2014·Circulation Research·Giuseppe Mancia, Guido Grassi
Jan 1, 2014·Emerging Themes in Epidemiology·Tom Loney, Nico J Nagelkerke
Feb 19, 2016·American Journal of Hypertension·Guido Grassi
Mar 30, 2017·Journal of Hypertension·Fosca Quarti TrevanoGuido Grassi
May 9, 2019·Hypertension·Elisabeth A LambertGavin W Lambert
Jun 18, 2019·Hypertension·Guido GrassiGiuseppe Mancia

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Citations

Feb 2, 2021·Cardiovascular Research·Larry ScottNa Li
Jun 3, 2021·Journal of Clinical Medicine·Mirko Parasiliti-CaprinoMauro Maccario
Jul 13, 2021·Frontiers in Cardiovascular Medicine·Zhuo-Ming HuangZhuo-Wen Huang
Nov 2, 2021·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Francesco GiallauriaCarmine Morisco

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