Sympathetic reflex responses during treatment of essential hypertension with hydrallazine and oxprenolol

British Journal of Clinical Pharmacology
I B DaviesT Rosenthal

Abstract

1. The short term effects of hydrallazine, oxprenolol and oxprenolol plus hydrallazine were studied in five patients with essential hypertension. 2. The increase in pulse rate caused by hydrallazine was prevented by combined treatment with oxprenolol, which also lowered the high plasma noradrenaline levels, associated with the use of hydrallazine. 3. Plasma renin activity was higher in the supine and standing positions with hydrallazine than with oxprenolol alone and with the patients standing this high renin level was prevented by simultaneous treatment with oxprenolol. With the patients supine, combination of oxprenolol with hydrallazine resulted in a mean plasma renin activity which was less than half that with hydrallazine alone, although this difference was not statistically significant. 4. The combination of oxprenolol with hydrallazine did not lower the blood pressure further, but reduced the increased sympathetic activity which occurred with hydrallazine alone.

References

Nov 24, 1979·British Medical Journal·I B Davies
Jun 1, 1984·British Journal of Clinical Pharmacology·D P NichollsR G Shanks
Jan 1, 1983·British Journal of Clinical Pharmacology·D P NichollsR G Shanks

Citations

Sep 18, 1976·Lancet·R Davies, J D Slater
May 21, 1977·Lancet·P S SeverR D Tunbridge
Jul 8, 1976·The New England Journal of Medicine·J W HollifieldD G Shand
Feb 1, 1975·Life Sciences·D P HenryR H Williams
Feb 1, 1969·Lancet·G W BoydW S Peart
Mar 23, 1972·The New England Journal of Medicine·R ZacestJ Koch-Weser
Jan 1, 1955·The Journal of Clinical Investigation·G G ROWEC W CRUMPTON

Related Concepts

Reflex Sympathetic Dystrophy
Physiologic Pulse
Sympathetic Nervous System
Diastolic Blood Pressure
Essential Hypertension
Norepinephrine, (+, -)-Isomer
Etiology
Hydralazine
Oxprenolol
Renin Measurement

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