Sympathetic regulation in rabbits with heart failure: experience using power spectral analysis of heart rate variability

Clinical and Experimental Pharmacology & Physiology
V A MoguilevskiB P McGrath

Abstract

1. In five intact rabbits beta-adrenoreceptor blockade (i.v. propranolol), and combined cardiac blockade (i.v. propranolol plus i.v. methscopolamine sulphate) revealed that spectral power of heart rate (HR) variability at low frequencies (LF:0.0625-0.1875 Hz) was modulated predominantly by the sympathetic nervous system and power at high frequencies (HF:0.4373-0.5625 Hz) by vagal influences. 2. In 16 rabbits resting power of HR at LF and changes in LF power in response to maximal treadmill exercise were examined prior to and after 4 and 6 weeks of doxorubicin treatment (1 mg/kg twice weekly). 3. The development of doxorubicin-induced congestive heart failure (CHF) was accompanied by a progressive increase in resting LF power [control, 8.5 +/- 2.1; 4 weeks, 13.4 +/- 1.8; 6 weeks, 21.9 +/- 3.5 (beats/min)2, P < 0.005]. 4. Power spectral analysis (PSA) of HR variability in the immediate post-exercise period showed no change from resting values in normal rabbits [5.3 +/- 1.4 vs 8.5 +/- 2.1 (beats/min)2, P > 0.05] whereas CHF rabbits showed falls in LF power after 4 weeks [4.6 +/- 1.0 vs 13.4 +/- 1.8 (beats/min)2, P < 0.005] and 6 weeks [6.5 +/- 2.4 vs 21.9 +/- 3.5 (beats/min)2, P < 0.005] of doxorubicin treatment. 5. It was conclud...Continue Reading

Citations

Jun 9, 2006·Bulletin of Experimental Biology and Medicine·N N AlipovN Z Abdulkerimova
Oct 1, 1996·Journal of Cardiovascular Pharmacology·G MaranoF Zanghi
Sep 6, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Alicia M SchillerIrving H Zucker
Apr 30, 2003·Journal of Applied Physiology·Rainer U PliquettIrving H Zucker

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