Sympathetic sprouting and changes in nociceptive sensory innervation in the glabrous skin of the rat hind paw following partial peripheral nerve injury

The Journal of Comparative Neurology
Laurene D YenAlfredo Ribeiro-Da-Silva

Abstract

Previous studies have suggested that sympathetic sprouting in the periphery may contribute to the development and persistence of sympathetically maintained pain in animal models of neuropathic pain. In the present study, we examined changes in the cutaneous innervation in rats with a chronic constriction injury to the sciatic nerve. At several periods postinjury, hind paw skin was harvested and processed by using a monoclonal antibody against dopamine-beta-hydroxylase to detect sympathetic fibers and a polyclonal antibody against calcitonin gene-related peptide to identify peptidergic sensory fibers. We observed migration and branching of sympathetic fibers into the upper dermis of the hind paw skin, where they were normally absent. This migration was first detected at 2 weeks, peaked at 4-6 weeks, and lasted for at least 20 weeks postlesion. At 8 weeks postlesion, there was a dramatic increase in the density of peptidergic fibers in the upper dermis. Quantification revealed that densities of peptidergic fibers 8 weeks postlesion were significantly above levels in sham animals. The ectopic sympathetic fibers did not innervate blood vessels but formed a novel association and wrapped around sprouted peptidergic nociceptive fibers...Continue Reading

References

May 1, 1989·Seminars in Arthritis and Rheumatism·M Zimmermann
Sep 4, 1987·Science·R Levi-Montalcini
Apr 1, 1981·Experimental Neurology·E M Korenman, M Devor
Jun 1, 1984·Journal of Neurosurgery·S Y GhostineC G Azar
Nov 1, 1982·Pain·J W ScaddingD M Brooks
Apr 1, 1995·Journal of Neurophysiology·D F Bossut, E R Perl
Feb 1, 1995·Journal of Neurochemistry·L M BolinJ S Abrams
Apr 1, 1993·Neuroreport·K M MearowJ Diamond
Oct 1, 1995·Pain·Erik TorebjörkMartin Koltzenburg

❮ Previous
Next ❯

Citations

Oct 13, 2006·European Journal of Applied Physiology·Magda Passatore, Silvestro Roatta
Jan 20, 2009·Human Reproduction·Guoyun WangIan S Fraser
Jan 25, 2008·Clinical and Experimental Pharmacology & Physiology·Gael F GibbsJacqueline K Phillips
Sep 23, 2011·Science Translational Medicine·Melissa A FarmerJeffrey S Mogil
Oct 19, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Guohua ZhangKaren J Berkley
Jan 12, 2012·Molecular Pain·Jennifer C Peleshok, Alfredo Ribeiro-da-Silva
Nov 5, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Juan M Jimenez-AndradePatrick W Mantyh
Feb 9, 2012·Journal of Visualized Experiments : JoVE·Andrew J Shepherd, Durga P Mohapatra
Jan 15, 2014·Autonomic Neuroscience : Basic & Clinical·Tanja SchlerethFrank Birklein
Aug 16, 2008·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Guido SaxlerUlrike Hanesch
Jun 13, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nemat Khan, Maree T Smith
Mar 12, 2010·Expert Opinion on Investigational Drugs·Rishabh DevAbhijit Ray
Jul 31, 2013·Molecular Pain·Maria OsikowiczAlfredo Ribeiro-da-Silva
Nov 12, 2013·The Journal of Pain : Official Journal of the American Pain Society·Eleanor S DrummondPeter D Drummond
Apr 19, 2011·The Journal of Pain : Official Journal of the American Pain Society·Aaron P BloomPatrick W Mantyh
Oct 27, 2009·Urology·Ugur YilmazClaire C Yang
Aug 19, 2007·The Journal of Pain : Official Journal of the American Pain Society·Chengshui ZhaoSrinivasa N Raja
Apr 14, 2009·The Journal of Comparative Neurology·Anna M W TaylorAlfredo Ribeiro-da-Silva
Nov 23, 2012·The Journal of Comparative Neurology·Abeer W Saeed, Alfredo Ribeiro-da-Silva
Dec 2, 2010·The Journal of Comparative Neurology·Jennifer C Peleshok, Alfredo Ribeiro-da-Silva
Dec 16, 2010·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Eduardo Martínez-MartínezGabriel Gutiérrez-Ospina
Oct 21, 2015·Clinical Hemorheology and Microcirculation·Liangli PanBiao Cheng
Feb 20, 2014·The Journal of Comparative Neurology·Romke BronJason J Ivanusic
Oct 13, 2006·Progress in Neurobiology·Antti Pertovaara
Jul 23, 2016·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·EungDon KimDaeHyun Jo
Dec 25, 2010·Neuroscience·L F DawsonP D Drummond
May 5, 2016·Autonomic Neuroscience : Basic & Clinical·Katia Puente de la Vega CostaLorenz Fischer
Oct 4, 2006·Neuron·James N Campbell, Richard A Meyer
Nov 19, 2008·Molecular Pain·Lina AlmarestaniAlfredo Ribeiro-da-Silva

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.