Sympathoadrenal system differentially affects photoperiodic changes in humoral immunity of Siberian hamsters (Phodopus sungorus)

Journal of Neuroendocrinology
G E DemasR J Nelson

Abstract

Siberian hamsters (Phodopus sungorus) rely on photoperiod as a primary cue to coordinate seasonally appropriate changes in physiology and behaviour. Among these seasonal changes is reduced immune function in short 'winter-like' days, compared to long 'summer-like' days. Previous evidence suggests that immune function is regulated, in part, by the sympathoadrenal system. The precise role of the sympathoadrenal system in regulating photoperiodic changes in immune function, however, remains unspecified. The goal of the present study was to examine the differential contributions of direct sympathetic innervation of immune target tissue, as well as adrenal medullary catecholamines, to photoperiodic changes in immune function in male Siberian hamsters. In Experiment 1, hamsters underwent either bilateral surgical removal of the adrenal medulla (ADMEDx), or sham surgeries, and were maintained in long (LD 16 : 8) or short days (LD 8 : 16). In Experiment 2, hamsters received either surgical denervation of the spleen, or sham surgeries, and were then housed in long or short days. Serum anti-KLH IgG concentrations and splenic norepinephrine (NE) content were determined in both experiments. Short-day hamsters had reduced humoral immunity c...Continue Reading

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Citations

Dec 7, 2006·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Devin A Zysling, Gregory E Demas
Oct 13, 2009·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Timothy J GreivesGregory E Demas
Jun 14, 2003·Proceedings. Biological Sciences·Gregory E DemasRandy J Nelson
Mar 16, 2011·The Journal of Animal Ecology·Gregory E DemasSusannah S French
Dec 16, 2010·Frontiers in Neuroendocrinology·James C WaltonRandy J Nelson
Dec 3, 2014·Frontiers in Neuroendocrinology·Tyler J Stevenson, Brian J Prendergast
Oct 21, 2009·Physiology & Behavior·Zhi-Jun ZhaoDe-Hua Wang
Oct 15, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Louis D Saravolatz, James Leggett
Dec 9, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Gregory E Demas
Sep 10, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Gregory E DemasDeborah L Drazen

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