PMID: 8597393Dec 29, 1995Paper

Sympathoadrenal system in stress. Interaction with the hypothalamic-pituitary-adrenocortical system

Annals of the New York Academy of Sciences
R KvetnanskýI J Kopin

Abstract

Exposure of an organism to any of a variety of stressors markedly activates the sympathoadrenal and hypothalamic-pituitary-adrenocortical systems. Interactions of these major stress systems occur at several levels in the periphery and the brain. In the present study, we used sham-operated or adrenalectomized cortisol-treated conscious rats to examine glucocorticoid effects on indices of CA release, metabolism, and synthesis, and on CA biosynthetic enzyme activities and gene expression at baseline and during immobilization stress (IMO). Adrenalectomy (ADX) stimulated basal and stress-induced increments in norepinephrine release, reuptake, metabolism, turnover, and biosynthesis. Loss of adrenomedullary hormones after ADX did not appear to contribute to these increments. Cortisol treatment reversed the ADX effects on CA indices and suppressed catecholaminergic responses to IMO in intact rats. These results suggest that endogenous glucocorticoids restrain responses of catecholamine turnover, synthesis, release, reuptake, and metabolism during stress. In contrast, in intact rats, continuous administration of cortisol lasting for 7 days exaggerated the IMO-induced increases in plasma CA levels. Inhibition of DOPA conversion to dopami...Continue Reading

References

Oct 28, 1977·Annals of the New York Academy of Sciences·J Axelrod
Apr 15, 1978·European Journal of Pharmacology·J W Dailey, T C Westfall
Dec 1, 1992·Molecular and Cellular Endocrinology·A Munck, A Náray-Fejes-Tóth
Nov 1, 1992·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·D L WongJ W Funder
May 1, 1990·Biological Psychiatry·R M Sapolsky, P M Plotsky
Jan 1, 1986·Journal of Neuroscience Research·M K StachowiakB B Kaplan
Jan 1, 1989·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·W JiangM C Bohn
May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·E E BaetgeR D Palmiter
Oct 1, 1988·The Journal of Endocrinology·S al-Damluji
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·A HärfstrandH Steinbusch
Jun 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·E J LewisD M Chikaraishi
Oct 1, 1988·Journal of Neurochemistry·G EisenhoferI J Kopin
Jan 1, 1986·Hormone Research·L J ValentaH Eisenberg
Apr 1, 1987·The Journal of Clinical Endocrinology and Metabolism·D S GoldsteinI J Kopin
Sep 1, 1988·Journal of the Autonomic Nervous System·G EisenhoferI J Kopin
Jan 1, 1988·The Journal of Clinical Investigation·D S GoldsteinI J Kopin
Oct 1, 1986·Physiological Reviews·B S McEwenW Rostene
Dec 1, 1987·The Journal of Surgical Research·R UdelsmanG P Chrousos
Apr 23, 1974·Biochemical and Biophysical Research Communications·R HoeldtkeS Kaufman
Nov 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·D M Chuang, E Costa

❮ Previous
Next ❯

Citations

Nov 10, 2010·Cellular and Molecular Neurobiology·David S Goldstein
Mar 10, 2012·Cellular and Molecular Neurobiology·R KvetnanskyP Vargovic
Nov 1, 1994·Brain Research. Molecular Brain Research·B HiremagalurE L Sabban
Aug 8, 1998·European Journal of Pharmacology·M J NijsenV M Wiegant
Oct 22, 2003·Physiology & Behavior·Alessandro BartolomucciAndrea Sgoifo
Nov 15, 2002·Survey of Ophthalmology·Evrydiki A BouzasConstantin J Pournaras
Oct 23, 1997·Brain Research. Molecular Brain Research·L SerovaE L Sabban
Mar 26, 2004·Psychoneuroendocrinology·Eva MikicsJózsef Haller
Mar 26, 2004·Psychoneuroendocrinology·Holger Ursin, Hege R Eriksen
Mar 19, 1999·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·I JerabekF B Jolicoeur
Mar 21, 2002·Journal of Neuroendocrinology·S A B E van AckerE R de Kloet
Jun 9, 2009·Shock·Rana I Sharara-ChamiJoseph A Majzoub
Sep 22, 2009·Canadian Journal of Physiology and Pharmacology·Adriana AdameovaNaranjan S Dhalla
Mar 13, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Andrea G BechtoldDeborah A Scheuer
Jul 24, 2002·Circulation Journal : Official Journal of the Japanese Circulation Society·Takashi UeyamaIchiro Nishio
Apr 18, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Takashi UeyamaKen-ichi Yoshida
Oct 8, 2003·The Japanese Journal of Physiology·Bihu GaoAkihiro Kuroshima
Feb 11, 2016·Scientific Reports·Georgios LolasKonstantinos N Syrigos
Feb 18, 2010·Journal of Research in Personality·Steven J Stanton, Oliver C Schultheiss
Jul 9, 2004·Annals of the New York Academy of Sciences·Jaromír MyslivecekRichard Kvetnanský

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.