Sympathoinhibitory action of nociceptin in the rat spinal cord

Clinical and Experimental Pharmacology & Physiology
G Cristina BrailoiuN J Dun

Abstract

1. Whole-cell patch recordings were made from antidromically identified sympathetic preganglionic neurons (SPN) of immature rat spinal cord slices. Bath application of nociceptin (0.1-1 micromol/L) suppressed excitatory postsynaptic potentials (EPSP) and hyperpolarized a population of SPN; these effects were naloxone (1 micromol/L) insensitive. 2. Nociceptin suppressed the amplitude of EPSP without causing a concomitant change in glutamate-induced depolarizations, suggesting a presynaptic inhibitory action. 3. Analysis of current-voltage relationships showed that nociceptin hyperpolarized SPN by increasing an inwardly rectifying K+ current. 4. Intrathecal injection of nociceptin (3, 10 and 30 nmol) to urethane-anaesthetized rats dose-dependently reduced the mean arterial pressure and heart rate; these effects were not prevented by prior intravenous injection of naloxone (1 mg/kg). 5. Results from our in vitro and in vivo experiments suggest that nociceptin suppresses spinal sympathetic outflow either by attenuating excitatory synaptic responses or hyperpolarizing SPN.

References

Jan 1, 1983·Annual Review of Pharmacology and Toxicology·J W Holaday
Apr 29, 1996·The Journal of Comparative Neurology·B AntonC J Evans
Nov 1, 1996·British Journal of Pharmacology·B NicolA T McKnight
Aug 27, 1997·European Journal of Pharmacology·S GiulianiC A Maggi
Nov 19, 1997·Neuroscience Letters·N J DunL L Hwang

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Citations

Nov 13, 2003·Peptides·Richard J Bodnar, Maria M Hadjimarkou
Jul 8, 2005·Brain Research·Vineet C Chitravanshi, Hreday N Sapru
Jan 22, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Vineet C Chitravanshi, Hreday N Sapru

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