Sympathovagal response to orthostatism in overt and in subclinical hyperthyroidism

Journal of Endocrinological Investigation
B GoichotC Simon

Abstract

Heart rate variability (HRV) is a measure of the physiological variation of R-R intervals, reflecting the sympathovagal balance. In both overt and subclinical hyperthyroidism, a relative increase in sympathetic activity has been demonstrated, mainly due to a decrease in vagal activity. The modifications of HRV during orthostatism in normal subjects resemble those seen in hyperthyroidism. We have studied the response of 19 patients with overt hyperthyroidism and 12 with subclinical hyperthyroidism during orthostatism using HRV and compared the results to those of 32 healthy controls. In the three groups, the R-R intervals decreased in the same proportion after orthostatism. The low frequency power (LF)/[LF + high frequency power (HF)] ratio, which reflects the sympathetic tone, also increased in the same proportion in the three groups. However, the mechanisms of the modulation of the sympathovagal balance during orthostatism were different among the three groups. In controls, the relative increase of sympathetic tone after orthostatism was due principally to a decrease in vagal tone (reflected by decreased power in the HF band), while in overt hyperthyroidism, where the power in the HF band was already minimal in the lying posit...Continue Reading

References

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Citations

Aug 22, 2008·American Journal of Physical Medicine & Rehabilitation·Jae Hyeok ChangHyun-Yoon Ko
Dec 17, 2009·International Archives of Occupational and Environmental Health·Mikio TakadaMichihiro Kamijima
Feb 21, 2019·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·I M Bensenor
Apr 10, 2008·The Journal of Clinical Endocrinology and Metabolism·Carmen F A Eustatia-RuttenJacobus Burggraaf
Aug 30, 2018·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·É J F Peixoto de MirandaI M Benseñor

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