Symptom burden and associated factors in renal transplant patients in the U.K.

Journal of Pain and Symptom Management
Maryam AfsharNizam Mamode

Abstract

Renal transplantation is gold standard care in end-stage kidney disease, but little is known about symptom prevalence in transplanted patients. This study assesses symptom prevalence in this population. This was a U.K.-based, cross-sectional symptom survey of end-stage kidney disease patients transplanted more than one year previously. Patient-reported data were collected using the renal Patient Outcome Scale. Demographic/clinical data also were collected, including estimated glomerular filtration rate (eGFR), renal diagnosis, and comorbidity. One hundred ten patients participated; mean age was 47 years (SD 13.6), and mean eGFR was 46 mL/min (SD 16.8, range 14-101). Symptom burden was high, with a mean of seven symptoms, but marked variance (SD 5.2, range 0-22). The most prevalent symptoms were weakness (56%, 95% CI 47-65), difficulty sleeping (46%, 95% CI 37-56), dyspnea (42%, 95% CI 33-51), feeling anxious (36%, 95% CI 28-46), and drowsiness (36%, 95% CI 28-46). Certain symptoms-weakness, difficulty sleeping, dyspnea, and drowsiness-were commonly reported as severe. A significant inverse relationship between renal function, as measured by eGFR, and number of symptoms (P<0.05) emerged. For renal transplant recipients, symptom ...Continue Reading

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Citations

Dec 18, 2013·Transplantation·Joseph ChilcotNizam Mamode
Apr 4, 2014·Kidney International·Micol ArtomJoseph Chilcot
Nov 10, 2015·Journal of Pain and Symptom Management·Amin AmroIngrid Os
Dec 2, 2015·Clinical Medicine : Journal of the Royal College of Physicians of London·Helen Alston, Aine Burns
Sep 4, 2015·Journal of Pain and Symptom Management·Emily S CollinsFliss E M Murtagh
Feb 15, 2015·Clinical Journal of the American Society of Nephrology : CJASN·Sarah L GoffMark Unruh
Feb 1, 2019·Journal of Patient-reported Outcomes·Elizabeth C LorenzDavid T Eton
Jan 11, 2020·Transplant International : Official Journal of the European Society for Organ Transplantation·Sumaya DanoIstvan Mucsi
Jan 4, 2020·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Han WangJie Zhao
Oct 23, 2020·Indian Journal of Palliative Care·Nengneivah HaokipSushma Bhatnagar
Jun 5, 2021·Clinical Kidney Journal·Yiman WangYvette Meuleman
Jun 23, 2021·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Claire Juliet MartinSusanna Maria Kassier
Aug 3, 2021·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Yiman WangYvette Meuleman

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