Symptom clusters in patients with bone metastases--a reanalysis comparing different statistical methods.

Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
Emily ChenEdward Chow

Abstract

The aims of this study were to determine whether symptom clusters in patients with bone metastases varied when derived using three different statistical methods and to compare the presentation of symptom clusters over time in responders and nonresponders to palliative radiation treatment (RT). Secondary analysis of a previously reported data set compiled using the brief pain inventory from 348 patients with bone metastases. Hierarchical cluster analysis (HCA) and exploratory factor analysis (EFA) were performed to identify symptom clusters at baseline, 1, 2, and 3 months following radiation treatment. Clusters derived were compared with the findings obtained using principal component analysis (PCA) in our previous study. The total patient sample was further separated into two subgroups: responders and nonresponders to RT. PCA, HCA, and EFA identified symptom clusters experienced by each subgroup at the same time points as before. Little correlation was observed in the symptom cluster findings of PCA, EFA, and HCA in the total patient sample. Absolute consensus among all three statistical methods was never reached at any assessment time point in the present study. Varying patterns of symptom cluster presentation over time were o...Continue Reading

References

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Jul 6, 2010·European Journal of Oncology Nursing : the Official Journal of European Oncology Nursing Society·Canhua Xiao

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Citations

Apr 8, 2014·Journal of Pain and Symptom Management·Skye Tian DongMeera Agar
Apr 22, 2014·Journal of Pain and Symptom Management·Aynur AktasBo Hu
Oct 26, 2016·Seminars in Oncology Nursing·Andrea Barsevick

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