Symptom combinations assessed in traditional Chinese medicine and its predictive role in ACR20 efficacy response in rheumatoid arthritis

The American Journal of Chinese Medicine
Yiting HeIan Tsang

Abstract

The predictive roles of symptom combination traditionally evaluated in traditional Chinese medicine (TCM) in the treatment of rheumatoid arthritis (RA) were explored. Three hundred and ninety six patients were randomly divided into 197 subjects receiving Western medicine therapy (WM) and 199 subjects receiving TCM therapy (TCM). A complete physical examination and 18 clinical manifestations typically assessed in TCM were recorded before the randomization. The ACR responses were used for efficacy evaluation. ACR20 and 50 responses with WM treatment were higher than in the TCM group. The 18 symptoms in RA could be clustered into 4 symptom combinations with factor analysis, which represent joint symptoms, cold pattern, deficiency pattern and hot pattern in TCM respectively. TCM would be more effective in patients with weak-symptom combination 3 (deficiency pattern in TCM), and WM would be more effective in patients with symptom combination 2 (cold pattern in TCM). Symptom combinations judged with TCM may have influence on the efficacy of therapy in the treatment of RA.

References

Jan 1, 1990·Epidemiologic Reviews·M C Hochberg, T D Spector
Sep 10, 1999·Psychosomatics·A J BarskyM H Liang
Mar 6, 2004·Lancet·Lars KlareskogUNKNOWN TEMPO (Trial of Etanercept and Methotrexate with Radiographic Patient Outcomes) study investigators
Apr 21, 2004·International Journal of Technology Assessment in Health Care·Rob M P M BaltussenChristopher J M Murray
Jun 29, 2004·World Journal of Gastroenterology : WJG·Ai-Ping LuQing-Ping Lu
Sep 21, 2010·TheScientificWorldJournal·Kevin S Choe, Stanley L Liauw
Dec 22, 2012·Epidemiologic Reviews·Tony RobertsonMichaela Benzeval

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Citations

Oct 15, 2008·Chinese Journal of Integrative Medicine·Ai-ping LuKe-ji Chen
Dec 6, 2012·Chinese Journal of Integrative Medicine·Byung-Cheul ShinYoung-Hun Cho
May 3, 2014·Chinese Journal of Integrative Medicine·Zhao-xiang BianHollie Cheung
Aug 27, 2013·The Cochrane Database of Systematic Reviews·Fiona CrampRobin Christensen
Dec 23, 2011·Nature·Peng Tian
Apr 4, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Sujeong MunSiwoo Lee

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