Symptom distress predicts long-term health and well-being in allogeneic stem cell transplantation survivors

Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Margaret BevansLi Yang

Abstract

The number of survivors after allogeneic hematopoietic stem cell transplantation (HSCT) continues to increase, yet their survivorship experience has not been fully characterized. This study examines the health status and health-related quality of life (HRQL) of HSCT survivors. The aims of the study were to: (1) explore the baseline and change over time in these health outcomes, and (2) characterize subgroups experiencing adverse outcomes. In this longitudinal study, adults who survived >3 years from date of allogeneic HSCT completed a series of patient-reported outcome measures annually, including measures of health status, HRQL, and symptoms. Data were analyzed using hierarchical linear modeling. Subjects (N = 171) were on average 44 (±13.5) years of age and primarily male (62.6%); 40% were Hispanic. Mean scores for physical and mental health and HRQL were preserved relative to population norms. Hierarchical linear modeling revealed no significant change in the mean trajectories of these outcomes, although significant between-individual variability was observed. When controlling for demographic and clinical factors, physical symptom distress negatively affected all outcomes. The impact of symptom distress on physical health va...Continue Reading

References

Apr 1, 1992·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·E Paci
Jan 4, 1995·JAMA : the Journal of the American Medical Association·I B Wilson, P D Cleary
Jul 10, 1999·Social Science & Medicine·M A Sprangers, C E Schwartz
Jul 4, 2001·Bone Marrow Transplantation·A GratwohlUNKNOWN European Group for Blood and Marrow Transplantation (EBMT)
Nov 5, 2002·Annual Review of Medicine·Frederick R Appelbaum
Oct 11, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Derek S SernaFausto R Loberiza
Feb 10, 2004·Cancer Treatment Reviews·Alberto RedaelliChris L Pashos
May 20, 2004·JAMA : the Journal of the American Medical Association·Karen L SyrjalaPaul J Martin
Jun 16, 2004·The Gerontologist·M Kristen PeekKenneth J Ottenbacher
Apr 27, 2005·Evaluation & the Health Professions·Penny S BruckerDavid Cella
Sep 8, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K Scott BakerDaniel J Weisdorf
Dec 13, 2005·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Alexandra H FilipovichMary E D Flowers
Mar 7, 2008·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Margaret F BevansSusan Marden
Mar 17, 2010·Bone Marrow Transplantation·S PalluaB Holzner
May 11, 2010·Journal of Cancer Survivorship : Research and Practice·Karen L SyrjalaJanet R Abrams
Aug 6, 2010·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·John R WingardMichelle M Bishop
Oct 29, 2011·Blood·Margaret F Bevans
Dec 8, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nandita KheraStephanie J Lee
Dec 20, 2011·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Navneet S MajhailUNKNOWN Sociedade Brasileira de Transplante de Medula Ossea (SBTMO)
Mar 27, 2012·Hematology/oncology and Stem Cell Therapy·N S MajhailUNKNOWN Sociedade Brasileira de Transplante de Medula Ossea (SBTMO)
Apr 6, 2012·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Pranav K GandhiTeresa L Kauf
Sep 21, 2012·Journal of Dental Research·H FassilS Z Pavletic
Sep 26, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Karen L SyrjalaStephanie J Lee
Oct 11, 2012·Cancer Nursing·Canhua XiaoDeborah Watkins Bruner
Jan 24, 2013·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Kristin BairdSteven Z Pavletic
May 30, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Theresa HahnNavneet S Majhail

❮ Previous
Next ❯

Citations

Feb 2, 2016·Bone Marrow Transplantation·A ImS Z Pavletic
Sep 1, 2015·Journal of Psychosocial Oncology·Patricia PrinceMargaret Bevans
Sep 25, 2014·Molecular Oncology·William A WoodEthan Basch
Sep 7, 2014·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Kelly KenzikJohn Wingard
Sep 16, 2016·Journal of Racial and Ethnic Health Disparities·M Magaña LópezG R Wallen
Feb 28, 2018·Current Hematologic Malignancy Reports·Gunjan L ShahSergio Giralt
Sep 26, 2017·PM & R : the Journal of Injury, Function, and Rehabilitation·Julie K Silver
Oct 10, 2014·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Paul GrossmanAlexander Kiss
Jan 6, 2018·Current Opinion in Supportive and Palliative Care·Sandra A Mitchell
Dec 8, 2019·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Emily A RosenthalLeora E Comis
Aug 24, 2018·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Jumin ParkMargaret F Bevans
Jul 26, 2018·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Eden R BrauerMarySue V Heilemann
Sep 14, 2017·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Aleksandra KroemekeZuzanna Kwissa-Gajewska
Aug 31, 2020·Bone Marrow Transplantation·John StrattonKristen Votruba
Jan 21, 2021·Journal of Psychosocial Oncology·Lisa BriceIan Kerridge
Apr 9, 2021·Transplantation and Cellular Therapy·Alessandro RacioppiAnthony D Sung

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.