Symptom Severity Following Rifaximin and the Probiotic VSL#3 in Patients with Chronic Pelvic Pain Syndrome (Due to Inflammatory Prostatitis) Plus Irritable Bowel Syndrome

Nutrients
Enzo VicariRoberto Castiglione

Abstract

This study investigated the effects of long-term treatment with rifaximin and the probiotic VSL#3 on uro-genital and gastrointestinal symptoms in patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) plus diarrhoea-predominant irritable bowel syndrome (D-IBS) compared with patients with D-IBS alone. Eighty-five patients with CP/CPPS (45 with subtype IIIa and 40 with IIIb) plus D-IBS according to the Rome III criteria and an aged-matched control-group of patients with D-IBS alone (n = 75) received rifaximin and VSL#3. The primary endpoints were the response rates of IBS and CP/CPPS symptoms, assessed respectively through Irritable Bowel Syndrome Severity Scoring System (IBS-SSS) and The National Institute of Health Chronic Prostatitis Symptom Index (NIH-CPSI), and performed at the start of therapy (V0) and three months after (V3). In IIIa prostatitis patients, the total NIH-CPSI scores significantly (p < 0.05) decreased from a baseline mean value of 21.2 to 14.5 at V3 , as did all subscales, and in the IIIb the total NIH-CPSI score also significantly decreased (from 17.4 to 15.1). Patients with IBS alone showed no significant differences in NIH-CPSI score. At V3, significantly greater improvement in the IBS-SS...Continue Reading

References

Dec 1, 1998·European Urology·T E Bjerklund JohansenP J van Cangh
Jul 28, 1999·JAMA : the Journal of the American Medical Association·J N KriegerJ C Nickel
Nov 28, 2002·Gastroenterology·Douglas A DrossmanWilliam E Whitehead
Mar 12, 2003·The Journal of Urology·Daniel A ShoskesCharles L Jackson
Oct 9, 2003·Scandinavian Journal of Gastroenterology·I K WiklundJ Naesdal
Jun 4, 2005·Alimentary Pharmacology & Therapeutics·A P S HunginV Barghout
Jul 27, 2005·Current Gastroenterology Reports·Christine L Frissora, Kenneth L Koch
Feb 10, 2006·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·K J PropertUNKNOWN Chronic Prostatitis Collaborative Research Network (CPCRN)
May 9, 2006·Gastroenterology·George F LongstrethRobin C Spiller
Jul 25, 2008·BMC Gastroenterology·Andrea K RoalfeSue Wilson
Sep 18, 2009·The Journal of Urology·María Angeles Bullones RodríguezUNKNOWN National Institute of Diabetes and Digestive and Kidney Diseases Working Group on Urological Chronic Pelvic Pain
Jan 6, 2011·Journal of Medical Engineering & Technology·R P ArasaradnamJ A Covington
Nov 3, 2011·The American Journal of Gastroenterology·Stacy B MeneesWilliam D Chey
Feb 11, 2012·Journal of Neurogastroenterology and Motility·Sanam Javid AnbardanHossein Ajdarkosh
Aug 3, 2014·BMC Urology·J Richard LandisUNKNOWN MAPP Research Network Study Group
Sep 19, 2014·World Journal of Gastroenterology : WJG·Rosa L S Soares
Jun 23, 2015·Journal of Neurogastroenterology and Motility·Tadayuki Oshima, Hiroto Miwa
Sep 10, 2015·Journal of Neurogastroenterology and Motility·Nazar MazurakPaul Enck
May 6, 2016·Gastroenterology·Douglas A Drossman, William L Hasler
Dec 3, 2016·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jerry M WellsClara L Garcia-Rodenas
Apr 14, 2017·The Lancet. Gastroenterology & Hepatology·Douglas A Drossman
Jun 9, 2017·Journal of Ultrasound·Saverio LatteriMario Scuderi
Jun 18, 2017·Expert Review of Gastroenterology & Hepatology·Wojciech MarliczAnastasios Koulaouzidis

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May 6, 2020·World Journal of Clinical Cases·Fang-Shu ChengLi-Xuan Sang

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