Symptom Severity of Restless Legs Syndrome Predicts Its Clinical Course

The American Journal of Medicine
Chung Suk LeeIn-Young Yoon

Abstract

This study examines the clinical course of restless legs syndrome according to its severity and factors associated with the remission of restless legs syndrome symptoms. The remission or persistence of restless legs syndrome symptoms was investigated by considering patients with restless legs syndrome at the sleep clinic of Seoul National University Bundang Hospital. All subjects were observed for at least 18 months, and an incidence of remission was defined as having no restless legs syndrome symptoms for at least 1 year. Restless legs syndrome severity was evaluated by the International Restless Legs Syndrome Study Group Rating Scale. A total of 306 patients participated in this study. Over the observation periods of 4.1 ± 1.6 years, the cumulative incidence of remission is 32.5% (95% confidence interval [CI], 27.0-38.0) and decreased with baseline restless legs syndrome severity (P < .001): 60% (95% CI, 44.9-75.1), 44% (95% CI, 34.4-53.6), and 16.7% (95% CI, 10.6-22.8) in mild, moderate, and severe to very severe restless legs syndrome cases, respectively. Most cases of remission (82/96) were observed within 1 year, and the remission occurred sooner for mild restless legs syndrome. The hazard ratios of remission by Cox propo...Continue Reading

References

Jan 1, 1997·Movement Disorders : Official Journal of the Movement Disorder Society·J MontplaisirP Lespérance
Jul 25, 2000·Archives of Internal Medicine·B PhillipsC Purvis
Nov 1, 2003·Sleep Medicine·Arthur S WaltersUNKNOWN International Restless Legs Syndrome Study Group
Sep 29, 2004·Lancet·Marie-Christine Chartier-HarlinAlain Destée
Jul 5, 2005·The American Journal of Psychiatry·Maria E FisfalenFrancis J McMahon
Oct 27, 2005·Diabetes Care·Lívia A LopesVeralice M S de Bruin
Jan 3, 2007·The American Journal of Medicine·Clete A Kushida
Feb 3, 2007·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Clete KushidaJohn E Ware
Jul 24, 2007·Sleep Medicine·S WhittomJ Montplaisir
Jun 11, 2008·Current Neurology and Neuroscience Reports·Juliane Winkelmann
Jul 2, 2008·Current Neurology and Neuroscience Reports·Lynn Marie TrottiDavid B Rye
May 16, 2009·Journal of Neurology·Claudia TrenkwalderJuliane Winkelmann
Sep 8, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Takeshi SekineNobutaka Hattori
Sep 5, 2013·Mayo Clinic Proceedings·Michael H SilberUNKNOWN Medical Advisory Board of the Willis-Ekbom Disease Foundation
Oct 11, 2013·Journal of Hypertension·Christina WesterdahlBengt Zöller
Jan 21, 2014·Journal of Affective Disorders·Niki Antypa, Alessandro Serretti

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Citations

Feb 28, 2018·Psychiatry Investigation·Young Rong BangIn-Young Yoon
Jun 20, 2017·Frontiers in Aging Neuroscience·Shiyi GuoTao Wang
Nov 22, 2019·British Journal of Neurosurgery·Amir Human HoveidaeiSeyed Hossein Owji
Sep 14, 2018·Journal of the Neurological Sciences·Hirotaka IwakiAlberto Ascherio

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