Symptomatic cerebrospinal fluid HIV-1 escape in two patients on second-line antiretroviral therapy in Uganda

Oxford Medical Case Reports
Kenneth SsebambuliddeAndrea Calcagno

Abstract

Two HIV-infected individuals on second-line atazanavir-based antiretroviral therapy presented with neuropsychiatric symptoms. Cerebrospinal fluid HIV RNA was higher than plasma HIV RNA and antiretroviral regimens' optimization led to prompt resolution of symptoms in one. Patients on second-line atazanavir-based antiretroviral therapy with documented previous treatment failure may be at risk of symptomatic cerebrospinal fluid escape.

References

Jan 27, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ana CanestriChristine Katlama
Oct 15, 2011·International Journal of STD & AIDS·R BinghamJ Green
Mar 23, 2017·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Shibani S MukerjiDana Gabuzda

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Citations

Dec 4, 2019·AIDS·Andrea MastrangeloPaola Cinque

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