Symptomatic dengue infection during pregnancy and livebirth outcomes in Brazil, 2007-13: a retrospective observational cohort study

The Lancet Infectious Diseases
Laura B NascimentoJoão B Siqueira

Abstract

Dengue is a major public health challenge in Brazil. We assessed the relationship between symptomatic dengue infection during pregnancy and adverse birth outcomes in the country between 2007 and 2013. We did a retrospective observational cohort study using information reported in the Brazilian national reportable disease information system (SINAN) and the livebirth information system (SINASC) databases. We probabilistically linked confirmed dengue-positive and dengue-negative pregnancies with live childbirths using Fine-Grained Record Integration and Linkage (FRIL) software. We also included an external reference population of randomly selected newborn babies. Pregnancy was adopted as the unit of analysis. We assessed the relationship between symptomatic dengue infection during pregnancy and adverse birth outcomes, using multivariable logistic regression adjusted for relevant covariates. 3898 dengue-positive pregnant women, 3165 dengue-negative women, and 3898 newborn babies from the reference population were included in the analysis. Preterm birth occurred in 322 (8·4%) of 3821 cases in the dengue-positive group versus 324 (10·4%) of 3101 in the dengue-negative group (unadjusted analysis: relative risk [RR] 0·81, 95% CI 0·70-0...Continue Reading

Citations

Aug 2, 2019·Viral Immunology·Lidong LiuYuan Chen
Oct 5, 2019·PLoS Neglected Tropical Diseases·Cíntia Pereira DonateliGlauce Dias da Costa
Apr 20, 2018·Reviews in Medical Virology·Ravi MehtaTom Solomon
Sep 19, 2020·Therapeutic Advances in Infectious Disease·Brendan O'Kelly, John S Lambert
Oct 17, 2019·Journal of Travel Medicine·Manon VougaMilos Stojanov
Jan 31, 2020·Wiener klinische Wochenschrift·Mujtaba MubashirRahat Qureshi
Aug 20, 2019·Journal of Travel Medicine·Scott Halstead, Annelies Wilder-Smith
May 26, 2021·Clinics in Perinatology·Annabelle de St MauriceAlison Chu

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