Symptomatic granular cell tumor of the pituitary gland: case report and review of the literature

Neurosurgery
B SchallerT Mindermann

Abstract

The posterior pituitary lobe is rarely the site of symptomatic primary tumors. The most common lesions arising from the neurohypophysis and the pituitary stalk seem to be granular cell tumors (GCTs), of which only 42 symptomatic cases have been reported. Here we present an unusually well-documented case of a GCT, which has implications for the differential diagnosis of sellar masses. A 75-year-old woman presented with decreased visual acuity, visual field loss, and a 2-year history of progressive vertigo and headaches. Neuroradiological studies showed a supra- and intrasellar, 25 x 20-mm mass, containing calcifications, that compressed the optic chiasm and extended into the third ventricle. The tumor was subtotally resected through a transsphenoidal approach. The tumor was tough and vascular and could not be suctioned. Histological examination revealed a typical GCT. The postoperative course was uneventful. Residual tumor was treated with fractionated radiation therapy. Ophthalmological testing 10 months after surgery showed a slight improvement in the visual symptoms. Tumor calcifications in computed tomographic scans do not exclude a GCT. The diagnosis requires histological confirmation. Surgical removal by the transsphenoida...Continue Reading

References

Jun 1, 1977·AJR. American Journal of Roentgenology·S D SholkoffL Silverman
Oct 1, 1979·The Journal of Pathology·A P Massie
Jan 1, 1991·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·H NishiokaA Hirano
Mar 1, 1966·Postgraduate Medical Journal·A Talerman, K Dawson-Butterworth
Jul 1, 1971·Journal of Neurosurgery·L SymonJ C Gonz
Sep 1, 1972·Archives of Ophthalmology·R R WallerT M Sundt
Oct 1, 1972·Journal of Neurosurgery·S Satyamurti, H W Huntington
Nov 1, 1984·Journal of Neurosurgery·C B Wilson
Feb 1, 1981·Neurosurgery·D H Becker, C B Wilson
Jan 1, 1981·Acta neurochirurgica·J VaqueroJ de Miguel
Apr 1, 1982·Journal of Neurosurgery·J F CusickL E Kun
Aug 1, 1995·Neuroradiology·C H JiT Chang
Sep 1, 1994·Clinical Endocrinology·T Mindermann, C B Wilson
Jun 1, 1994·Journal of Neurosurgery·C LafitteM Jan
Sep 1, 1958·Journal of Neurosurgery·L LISS, E A KAHN
Apr 1, 1962·The Journal of Pathology and Bacteriology·J BURSTONH SPENCER
May 1, 1964·American Journal of Clinical Pathology·E P JENEVEIN
Jan 1, 1965·Journal of Neurosurgery·Y DORONA J BELLER

❮ Previous
Next ❯

Citations

Jun 26, 2001·Pathology International·S OgataS Tamai
Mar 10, 2017·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Shun YamamuroAtsuo Yoshino
Sep 15, 2015·Journal of the Belgian Society of Radiology·A GregoireC Godfraind
Mar 14, 2019·Reviews in Endocrine & Metabolic Disorders·Fernando Guerrero-PérezCarles Villabona
Aug 23, 2007·American Journal of Physiology. Endocrinology and Metabolism·Kathleen C HornerNicole Sauze
Aug 30, 2008·Neurosurgery·Stacey Quintero WolfeJacques J Morcos
Jun 1, 2010·Journal of Neurosurgery·Michael L MumertWilliam T Couldwell
May 21, 2011·Pituitary·Ariyan Pirayesh IslamianRudolf Fahlbusch
May 25, 2013·Brain Pathology·Bette K Kleinschmidt-DeMasters, M Beatriz S Lopes
Jan 1, 2013·Journal of Case Reports in Medicine·Jennifer L OrningAnand V Germanwala
Mar 26, 2013·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Cona C AnwerErik R Wisner
Jul 8, 2000·Pathology International·S KasashimaI Nakanishi
Oct 6, 2007·Endocrine Pathology·Vera PopovicKalman Kovacs
Mar 7, 2013·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Filippo GagliardiPietro Mortini
Aug 25, 2018·Journal of Neuro-oncology·Jessica B PolasekEkkehard M Kasper
Jan 25, 2003·Journal of Computer Assisted Tomography·Mark D WilkinsonMichael Besser
Sep 1, 2005·Virchows Archiv : an International Journal of Pathology·Paulo R Benites FilhoLuiz F Bleggi Torres
Feb 15, 2001·Archives of Pathology & Laboratory Medicine·T J CummingsR E McLendon
Oct 6, 2005·Clinical Neurology and Neurosurgery·Bernhard Schaller

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved