Symptomatic muscular sarcoidosis: Lessons from a nationwide multicenter study

Neurology. Neuroimmunology and Neuroinflammation
Fleur Cohen AubartDominique Valeyre

Abstract

To describe clinicopathologic features of muscular sarcoidosis and the associated sarcoidosis phenotype through a nationwide multicenter study. Patients were included if they had histologically proven sarcoidosis and symptomatic muscular involvement confirmed by biological, imaging, or histologic examinations. Forty-eight patients (20 males) were studied, with a median age at muscular symptoms onset of 45 years (range 18-71). Four patterns were identified: a nodular pattern (27%); smoldering phenotype (29%); acute, subacute, or progressive myopathic type (35%); and combined myopathic and neurogenic pattern (10%). In all patterns, sarcoidosis was multivisceral with a median of 3 extramuscular organs involved (mostly lungs, lymph nodes, eyes, and skin) and a prolonged course with long-term use of corticosteroids and immunosuppressive drugs. Muscular patterns differed according to clinical presentation (myalgia, nodules, or weakness), electromyographic findings, muscular MRI, and response to sarcoidosis treatment. The myopathic and neuromuscular patterns were more severe. This nationwide study of muscular sarcoidosis allowed the identification of 4 patterns of granulomatous myositis, which differed by phenotypes and the clinical c...Continue Reading

References

May 1, 1987·Seminars in Arthritis and Rheumatism·S M WolfeR E Goodman
Dec 1, 1973·Journal of Neurology, Neurosurgery, and Psychiatry·A C DouglasJ D Matthews
Sep 1, 1969·Archives of Neurology·A Silverstein, L E Siltzbach
Sep 25, 1998·Journal of Neurology·T MozaffarA Pestronk
Apr 21, 1999·QJM : Monthly Journal of the Association of Physicians·J P ZajicekD Mitchell
Mar 1, 1958·Annals of Internal Medicine·S L WALLACEC RAGAN
Mar 10, 2006·Journal of the Neurological Sciences·T M BurnsP J Dyck
Oct 28, 2006·Muscle & Nerve·Karine Le RouxPascal Sève
Jul 19, 2008·Lancet Neurology·Nizar SouayahLeroy R Sharer
Oct 5, 2013·Lancet·Dominique ValeyreJoachim Müller-Quernheim
Oct 3, 2014·Clinical Reviews in Allergy & Immunology·Marc A Judson
Feb 26, 2015·Journal of Neurology·Shinya MaeshimaGen Sobue
Nov 26, 2016·La Revue de médecine interne·F Cohen AubartZ Amoura

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Citations

Nov 18, 2018·Acta Neurologica Scandinavica·Assunta Dal-BiancoSabine Salhofer-Polanyi
Apr 19, 2018·Neurology. Neuroimmunology and Neuroinflammation·Josep Dalmau
Jun 2, 2020·Muscle & Nerve·Stefan NicolauMargherita Milone
May 29, 2020·Expert Review of Respiratory Medicine·Spyros A PapirisSofia Chatziioannou
Feb 10, 2021·International Journal of Rheumatic Diseases·Sanjeev PatilNamrata Singh
Nov 30, 2020·La Revue de médecine interne·F FerO Benveniste
Jun 19, 2021·Pulmonary Therapy·Andrea S MelaniElena Bargagli
Jul 24, 2021·Advances in Therapy·Dominique ValeyreJean-François Bernaudin
Oct 6, 2021·Neurology. Neuroimmunology and Neuroinflammation·Michael J BradshawJeffrey M Gelfand
Dec 25, 2021·Journal of Clinical Ultrasound : JCU·Isidora Grozdic MilojevicVera M Artiko

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Methods Mentioned

BETA
biopsy
biopsies

Software Mentioned

GraphPad Prism
GraphPad

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