Symptomatic response rates to testosterone therapy and the likelihood of completing 12 months of therapy in clinical practice

The Journal of Sexual Medicine
Ernani Luis Rhoden, Abraham Morgentaler

Abstract

Despite increasing medical interest in testosterone therapy (TTh) for men with testosterone deficiency (TD) there is limited information regarding subjective response rates and acceptability of medium- to long-term TTh in routine clinical practice. To evaluate results in a consecutive series of men in clinical practice treated with TTh. A chart review was performed for a consecutive series of men for whom TTh was initiated over 1 year for a clinical diagnosis of TD. A diagnosis of TD was based on the presence of symptoms and on laboratory evaluation indicating total testosterone (<300 ng/dL) or free testosterone (FT) (<1.5 ng/dL). Presenting symptoms were noted at baseline, and improvement was documented in domains of erectile function, libido, energy,and mood. Percentage of men who completed 12 months of TTh, and symptomatic response rates. There were 127 men included in the evaluation. The most common presenting symptoms were the combination of erectile dysfunction (ED) and reduced libido in 82 (64.6%), ED alone in 29 (22.8%), and reduced libido alone in 13 (10.2%). Initial mode of TTh was injections (testosterone enanthate or cypionate) in 70 (55.1%)and transdermal gel (Androgel, Solvay Pharmaceuticals, Marietta, GA, USA) in...Continue Reading

References

Jun 1, 1997·The Journal of Clinical Endocrinology and Metabolism·R SihC Ross
Nov 14, 1997·The Journal of Clinical Endocrinology and Metabolism·R R HajjarJ E Morley
Jan 29, 1999·Endocrinology and Metabolism Clinics of North America·J L Tenover
Oct 16, 1999·The Journal of Clinical Endocrinology and Metabolism·A VermeulenJ M Kaufman
Apr 25, 2000·Molecular and Cellular Endocrinology·M Zitzmann, E Nieschlag
Feb 7, 2001·The Journal of Clinical Endocrinology and Metabolism·S M HarmanUNKNOWN Baltimore Longitudinal Study of Aging
Apr 26, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·A M KennyL G Raisz
Sep 27, 2001·Endocrinology and Metabolism Clinics of North America·B D Anawalt, G R Merriam
Oct 6, 2005·International Journal of Urology : Official Journal of the Japanese Urological Association·Kikuo OkamuraHiroshi Shimokata
May 25, 2006·The Journal of Clinical Endocrinology and Metabolism·Shalender BhasinVictor M Montori
Nov 8, 2006·The Journal of Sexual Medicine·Luis Reyes-VallejoAbraham Morgentaler
Feb 8, 2007·The Journal of Clinical Endocrinology and Metabolism·Abraham Morgentaler
Jun 9, 2007·BJU International·E David CrawfordAbraham Morgentaler
May 21, 2009·The Journal of Sexual Medicine·Jukka HintikkaHeimo Viinamäki
May 29, 2009·The Journal of Sexual Medicine·Sergio A Moreno, Abraham Morgentaler

❮ Previous
Next ❯

Citations

Jul 15, 2011·International Journal of Impotence Research·A W PastuszakM Khera
Sep 13, 2012·Patient Preference and Adherence·Sheryl L SzeinbachKent H Summers
Sep 3, 2011·The Journal of Sexual Medicine·William ConnersAbraham Morgentaler
Dec 19, 2013·The Journal of Sexual Medicine·Jason R KovacLarry I Lipshultz
Jun 10, 2014·The Journal of Sexual Medicine·Craig DonatucciDavid Muram
Mar 29, 2014·International Journal of Clinical Practice·E F ShortridgeB Carswell
May 3, 2016·The Urologic Clinics of North America·Joseph Scott GabrielsenMichael L Eisenberg
Aug 17, 2016·Pharmacoepidemiology and Drug Safety·Diana MartinsUNKNOWN Ontario Drug Policy Research Network
Dec 24, 2010·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Robert M CowardCulley C Carson
Feb 8, 2011·International Journal of STD & AIDS·T LyonsG Pinna
Jan 26, 2012·Toxicology and Industrial Health·Mahaneem MohamedKuttulebbai Nainamohamed Salam Sirajudeen
Jan 31, 2012·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Louis J Gooren, Hermann M Behre
Jan 24, 2021·Endocrine Reviews·David J Handelsman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Arquivos de neuro-psiquiatria
André Palma da Cunha Matta, Pedro F Moreira Filho
The Journal of Sexual Medicine
Emmanuele A JanniniWayne J G Hellstrom
© 2021 Meta ULC. All rights reserved