PMID: 15218414Jun 26, 2004Paper

Symptomatic thrombosis in Turkish neonates

Journal of Pediatric Hematology/oncology
Aytemiz GurgeyFatmanur Cakmak

Abstract

To investigate the association of two common prothrombotic mutations, factor V G1691A (FV G1691A) and prothrombin G20210A (PT G20210A), in neonates with thrombosis. Twenty-six neonates with thrombosis were assessed with the spectrum of assays for thrombophilia, including the two DNA-based prothrombotic factors. Eight patients (31%) had the FV G1691A mutation in heterozygous state. PT G20210A mutation was detected in four patients (15%). Overall, two common prothrombotic factors were detected in 12 neonates (46%) and an underlying disease or a triggering event in 18 neonates (69%). Thrombosis was considered to be idiopathic in five neonates (19%). The pathogenesis of thrombosis in neonates is multi-factorial. Along with underlying diseases or triggering events, congenital prothrombotic factors (FV G1691A and PT G20210A) showed a trend toward a higher frequency in neonates with thrombosis. These data indicate that mutations associated with underlying disorders in neonates may contribute to the development of thromboembolic disease.

References

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Citations

Nov 24, 2006·Journal of Perinatology : Official Journal of the California Perinatal Association·J WiebersV Milisavljevic
Jan 18, 2005·Journal of Pediatric Hematology/oncology·Lionel CarbillonMarie-Helene Aurousseau
Aug 15, 2013·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Galit RashishUNKNOWN Thrombosis and Hemostasis in Newborns (THiN) Group
Jul 16, 2014·Journal of Clinical Neonatology·Alireza AbdollahiBehnaz Mahdaviani
Sep 25, 2015·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Nafisa H R AbdelAzizTahra Sherif
Nov 29, 2011·The Journal of International Medical Research·S CalkavurN Kultursay
Feb 12, 2009·Pediatric Hematology and Oncology·Namik OzbekFatma Belgin Atac
Jan 29, 2011·Pediatric Hematology and Oncology·Fuat Emre Canpolat, Ferhat Cekmez

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