Symptomatic treatment of children with anti-NMDAR encephalitis

Developmental Medicine and Child Neurology
Shekeeb S MohammadRussell C Dale

Abstract

We performed the first study on the perceived benefit and adverse effects of symptomatic management in children with anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis. A retrospective chart review was undertaken at two tertiary paediatric hospitals in Australia and New Zealand. We included 27 children (12 males, 15 females; mean age at admission 7y 1mo) with anti-NMDAR antibodies in serum or cerebrospinal fluid with a typical clinical syndrome. Only two out of 27 patients were white, whereas 16 out of 27 patients were from the Pacific Islands/New Zealand Maori. The mean duration of admission was 69 days (10-224d) and 48% of patients (13/27) needed treatment in an intensive care setting. A mean of eight medications per patient was used for symptomatic management. Symptoms treated were agitation (n=25), seizures (n=24), movement disorders (n=23), sleep disruption (n=17), psychiatric symptoms (n=10), and dysautonomia (n=four). The medications used included five different benzodiazepines (n=25), seven anticonvulsants (n=25), eight sedatives and sleep medications (n=23), five antipsychotics (n=12), and five medications for movement disorders (n=10). Sedative and sleep medications other than benzodiazepines were the most effect...Continue Reading

References

Dec 1, 1988·Stroke; a Journal of Cerebral Circulation·R Bonita, R Beaglehole
Aug 23, 2003·Journal of Neurology, Neurosurgery, and Psychiatry·A L TeixeiraM C Cunningham
May 2, 2008·PLoS Biology·Emmanuel Mignot
Dec 19, 2008·The American Journal of Emergency Medicine·Reuben J Strayer, Lewis S Nelson
Mar 25, 2009·Archives of Disease in Childhood·M SchimmelJ Penzien
Nov 26, 2009·Annals of Neurology·Russell C DaleAngela Vincent
Dec 18, 2010·Lancet Neurology·Josep DalmauRita Balice-Gordon
Mar 4, 2011·The American Journal of Psychiatry·Meredith R Chapman, Holly E Vause
May 17, 2011·Child and Adolescent Psychiatry and Mental Health·Angèle ConsoliDavid Cohen
Jul 5, 2011·The American Journal of Psychiatry·Dirk DhosscheLee E Wachtel
Sep 16, 2011·Anesthesia and Analgesia·Peter Gabriel PryzbylkowskiLinda Chen
Mar 27, 2012·Psychiatry and Clinical Neurosciences·Takuya MatsumotoSatoshi Kato
Jun 16, 2012·Movement Disorders : Official Journal of the Movement Disorder Society·Maria StamelouKailash P Bhatia
Apr 16, 2014·General Hospital Psychiatry·Preetha S KuppuswamyChristopher L Sola
Jan 1, 2013·Case Reports in Critical Care·Michael MacMahonJonathan Rhodes
Aug 27, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Shekeeb S MohammadRussell C Dale
Dec 6, 2014·Cell Communication and Signaling : CCS·Narasimhulu SimmaUrsula Bommhardt

❮ Previous
Next ❯

Citations

Nov 13, 2015·Expert Review of Neurotherapeutics·Margherita NosadiniRussell C Dale
Jun 4, 2016·Developmental Medicine and Child Neurology·Yael HacohenJean-Pierre Lin
Jun 28, 2016·Clinical Neurology and Neurosurgery·Ali Seifi, Deanna L Kitchen
Jun 23, 2016·Paediatrics and International Child Health·Fahad A BashiriMustafa A Salih
Oct 16, 2015·Developmental Medicine and Child Neurology·Jonathan Gadian, Ming Lim
Feb 25, 2017·Current Opinion in Neurology·Russell C DaleMing Lim
Mar 23, 2017·Developmental Medicine and Child Neurology·Hannah F JonesCynthia Sharpe
Jun 22, 2018·Nature Reviews. Neurology·Elizabeth WellsUNKNOWN attendees of the International Neuroimmune Meeting
Sep 16, 2018·Movement Disorders : Official Journal of the Movement Disorder Society·Valentina DamatoSarosh R Irani
Oct 20, 2018·Acta Neurologica Scandinavica·Deepa Dash, Sanjay Pandey
Mar 29, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Shekeeb S MohammadRussell C Dale
Dec 20, 2016·Journal of Child and Adolescent Psychopharmacology·Lauren T SchumacherJames G MacKenzie
Jun 9, 2019·Developmental Medicine and Child Neurology·Margherita NosadiniUNKNOWN Italian Working Group on Paediatric Anti-N-methyl-D-aspartate Receptor Encephalitis
Jan 11, 2020·Frontiers in Pediatrics·Sara MatricardiAlberto Verrotti
Nov 20, 2019·Psychological Medicine·Nicola WarrenDan Siskind
Nov 22, 2016·Developmental Medicine and Child Neurology·Bernard Dan
Jan 30, 2021·Journal of Psychiatric Research·Margo ThienemannJennifer Frankovich
Oct 16, 2020·Archives of Physical Medicine and Rehabilitation·Gabrielle AlvarezRobyn Howarth
Mar 3, 2021·Journal of Neurology, Neurosurgery, and Psychiatry·Hesham AbboudUNKNOWN Autoimmune Encephalitis Alliance Clinicians Network
Dec 16, 2020·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·F UrsittiM Valeriani
Apr 25, 2021·Seminars in Pediatric Neurology·Melissa L HutchinsonThaís Armangue
Jun 3, 2021·BJPsych Bulletin·Matthew BeattieRajeev Krishnadas
Jun 4, 2021·International Medical Case Reports Journal·Joe Rakiro, Dilraj Sokhi
Jul 18, 2021·Current Problems in Pediatric and Adolescent Health Care·Ajay GoenkaGogi Kumar
Jul 18, 2021·European Archives of Psychiatry and Clinical Neuroscience·R RoselloS Taylor

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Anti-N-Methyl-D-Aspartate Receptor Encephalitis

Anti-N-Methyl-D-Aspartate (NMDA) receptor encephalitis is a form of of brain inflammation due to antibodies against NMDA receptors. Discover the latest research on anti-NMDA receptor encephalitis here.

Related Papers

Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
Yu-Wu Jiang, Tao-Yun Ji
Movement Disorders : Official Journal of the Movement Disorder Society
José Fidel Baizabal-CarvalloJoseph Jankovic
The Journal of Neuropsychiatry and Clinical Neurosciences
Sameer Belvi MangalwedheRajendra I Dugani
© 2021 Meta ULC. All rights reserved