Symptomatic venous thromboembolism following fractures distal to the knee: a nationwide Danish cohort study

The Journal of Bone and Joint Surgery. American Volume
Liv Riisager WahlstenJonas Bjerring Olesen

Abstract

Our aims were to determine the incidence of symptomatic deep venous thrombosis (DVT) and pulmonary embolism (PE) that required inpatient or outpatient treatment, and to identify specific risk factors associated with DVT/PE in patients who had undergone surgery for a fracture distal to the knee. Using individual linkage of nationwide registries, we included all Danish patients who had undergone surgery for a fracture distal to the knee between 1999 and 2011. Patients were followed for 180 days from discharge. Event rates of DVT/PE were calculated, and significant risk factors were identified with use of multivariable Cox regression analyses. Routine postdischarge antithrombotic chemoprophylaxis was not given to these patients. The study included 57,619 patients, 594 of whom had a venous thromboembolic event during the follow-up period. Thirty-nine (6.6%) of the 594 events were death due to PE. The overall event rate during the 180-day study period was 1.0%. The incidence rate was 7.28 events per 100 person-years before discharge, decreasing to a stable level below one event per 100 person-years in week 13 to 14 after discharge. Use of oral contraception by patients eighteen to fifty years of age (hazard ratio [HR] = 5.23, 95% co...Continue Reading

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Citations

Jul 17, 2018·VASA. Zeitschrift für Gefässkrankheiten·Jan Beyer-WestendorfHannelore Rott
Oct 3, 2018·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Robert M PrinceChristopher W DiGiovanni
Jul 14, 2019·Journal of Thrombosis and Haemostasis : JTH·Noémie KraaijpoelGrégoire Le Gal
Oct 2, 2019·The American Journal of Sports Medicine·Melissa Hornbæk PedersenAnders Nissen Bonde
Mar 27, 2020·Research and Practice in Thrombosis and Haemostasis·Susan R Kahn, Sudeep Shivakumar

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