Symptoms suggestive of cow's milk allergy in infancy and pediatric inflammatory bowel disease

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
Lauri VirtaKaija-Leena Kolho

Abstract

Risk factors of pediatric inflammatory bowel disease (PIBD) are incompletely understood. Recently, we reported that among patients with PIBD, a previous diagnosis of cow's milk allergy (CMA) and asthma occurred more frequently than among age- and sex-matched peers. We tested at a national level the hypothesis that CMA is associated with the risk of contracting PIBD. A nationwide birth cohort (n = 225,041), including all Finnish children born between 1999 and 2002, was followed up until July 1, 2014. We identified all children with a diagnosis of CMA, asthma, and PIBD from a national register; the data were based on certificates, including diagnostic criteria. The 95% confidence intervals (CI) for the incidence rates per 100,000 person-years were calculated assuming a Poisson distribution. We identified 7,910 infants with CMA yielding a cumulative incidence of 3.5% by 2 years of age. The cumulative incidence of PIBD was 0.14% (n = 316) and that of asthma 6.6% (14,807). Children with CMA were more likely to develop PIBD than non-CMA children, incidence ratio 2.6 (95% CI 1.7-3.8). Children with a diagnosis of CMA contracted PIBD at a younger age than the respective non-CMA group (9 vs. 11 years, p < 0.05). The risk was more eviden...Continue Reading

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Citations

Jun 21, 2016·Expert Review of Clinical Immunology·Kaija-Leena Kolho, Antti Ainamo
Dec 19, 2018·Nutrients·Andrew Szilagyi, Norma Ishayek
Nov 9, 2017·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Carla MastrorilliKarin Hoffmann-Sommergruber
Oct 27, 2017·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Ulrich WahnIoana Agache
Mar 5, 2019·Frontiers in Immunology·Roberto Berni CananiDanilo Ercolini
Jan 5, 2021·Journal of Pediatric Gastroenterology and Nutrition·Ana Muñoz-UrribarriYovani M Condorhuamán
Jun 6, 2020·Endocrinología, Diabetes Y Nutrición·Mariangela RondanelliAlessandra Miccono
May 27, 2021·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Pabitra SahuRakesh K Tandon

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