PMID: 9661306Jul 14, 1998Paper

Synanthropic rodent reservoirs of Trypanosoma (Schizotrypanum) cruzi in the valley of Caracas, Venezuela

Revista Do Instituto De Medicina Tropical De São Paulo
L Herrera, Servio Urdaneta-Morales

Abstract

Direct blood examination and xenodiagnosis of 47 synanthropic rodents (Rattus rattus, R. norvegicus, Mus musculus) captured in the valley of Caracas, Venezuela, revealed trypanosomal infections in 12 R. rattus, 10 with T. lewisi and 2 with T. cruzi. Of the latter the course of parasitemia, the pleomorphism of the bloodstream trypomastigotes, tissue in naturally and experimentally infected rats and mice, host mortality, morphology of fecal parasites in Rhodnius prolixus used for xenodiagnosis, and infectivity of the bug feces for NMRI mice, were all characteristic of Trypanosoma (Schizotrypanum) cruzi. One rat, with a patent parasitemia, had numerous nests of amastigotes in cardiac muscle and moderate parasitism of the smooth muscle of the duodenum and of skeletal muscle. Mice inoculated with fecal flagellates from the bugs had moderate tissue tropism in the same organs and also in the colon and pancreas. The possible role of R. rattus in the establishment of foci of Chagas' disease in Caracas is discussed.

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Citations

Aug 14, 2001·Memórias do Instituto Oswaldo Cruz·L Herrera, Servio Urdaneta-Morales
Jun 6, 2002·Memórias do Instituto Oswaldo Cruz·Pedro Marcos Linardi, José Ramiro Botelho
Oct 31, 2006·Memórias do Instituto Oswaldo Cruz·Antonio R L TeixeiraNancy R Sturm
Jun 30, 2018·PLoS Neglected Tropical Diseases·Cécile CassanAnne-Laure Bañuls
Feb 20, 2007·The Journal of Parasitology·C Miguel PintoMario J Grijalva
Jun 25, 2009·Critical Reviews in Microbiology·Bastiaan G MeerburgAize Kijlstra
Nov 16, 2020·Parasites & Vectors·Bruno M GhersiMichael J Blum