Synapse-specific metaplasticity: to be silenced is not to silence 2B.

Neuron
Benjamin D Philpot, R Suzanne Zukin

Abstract

What happens to a single, presynaptically quiescent synapse among a population of active synapses? In this issue of Neuron, Ehlers and colleagues show that, far from being eliminated, these inactive synapses are primed for potentiation and incorporation into a new neural circuit through an upregulation of NR2B-containing NMDA receptors.

References

Oct 21, 2004·Science's STKE : Signal Transduction Knowledge Environment·Stuart G Cull-Candy, Daniel N Leszkiewicz
Jul 1, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Aleksander SobczykKarel Svoboda
May 22, 2007·Nature Reviews. Neuroscience·C Geoffrey Lau, R Suzanne Zukin
Sep 6, 2007·Neuron·Camilla Bellone, Roger A Nicoll
Apr 11, 2008·Nature Reviews. Neuroscience·Wickliffe C Abraham
Nov 11, 2008·Neuron·Sacha B Nelson, Gina G Turrigiano
Mar 23, 2010·Trends in Neurosciences·Dan Ohtan WangR Suzanne Zukin
Jul 14, 2010·Neuron·Ming-Chia LeeMichael D Ehlers

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Citations

Jun 25, 2014·Trends in Pharmacological Sciences·Yan Dong, Eric J Nestler
Nov 13, 2015·Journal of Neurochemistry·Kristin Bobsin, Hans-Jürgen Kreienkamp
Oct 25, 2011·Developmental Neurobiology·Zane R Lybrand, Mark J Zoran
Mar 29, 2016·Neural Plasticity·Sung-Soo Jang, Hee Jung Chung
Oct 20, 2012·Nature Reviews. Neuroscience·Leon N Cooper, Mark F Bear
Jan 21, 2018·Current Opinion in Neurobiology·Jee-Yeon Hwang, R Suzanne Zukin

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