Synapsins in the vertebrate retina: absence from ribbon synapses and heterogeneous distribution among conventional synapses

Neuron
J W MandellP De Camilli

Abstract

The vertebrate retina contains two ultrastructurally distinct types of vesicle-containing synapses: conventional synapses, made predominantly by amacrine cells, and ribbon synapses, formed by photoreceptor and bipolar cells. To identify molecular differences between these synapse types, we have compared the distribution of the synapsins, a family of nerve terminal phosphoproteins, with that of synaptophysin (p38) and SV2, two intrinsic membrane proteins of synaptic vesicles. We report an absence of synapsin I and II immunoreactivity from all ribbon-containing nerve terminals. These include terminals of rod cells in developing and adult rat retina, rod and cone cells in monkey and salamander retinas, and rat bipolar cells. Furthermore, we show that synapsins I and II are differentially distributed among conventional synapses of amacrine cells. The absence of the synapsins from ribbon synapses suggests that vesicle clustering and mobilization in these terminals differ from that in conventional synapses.

References

Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Apr 1, 1977·Journal of Neurocytology·H Kolb, R W West
Feb 6, 1986·Nature·H M SakaiJ E Dowling
Jun 1, 1986·The Journal of Comparative Neurology·T Voigt
Dec 15, 1989·The Journal of Comparative Neurology·E Townes-Anderson, B A Vogt
Dec 15, 1986·Biochemical Pharmacology·P De Camilli, P Greengard
Apr 16, 1987·Nature·M Bähler, P Greengard
Nov 1, 1987·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·D Hicks, C J Barnstable
Dec 1, 1985·Developmental Biology·P V Sarthy, W Bacon
Apr 12, 1985·Science·R D Fields, M H Ellisman
Sep 1, 1967·The Journal of Physiology·B Katz, R Miledi
Dec 10, 1971·Brain Research·E G Gray, H L Pease
May 1, 1970·Biophysical Journal·W A HaginsS Yoshikami
Dec 1, 1970·The Journal of Comparative Neurology·L Sosula, P H Glow
Sep 30, 1966·Science·J E DowlingD Major
Dec 17, 1982·Journal of Immunological Methods·G D JohnsonE J Holborow
Feb 1, 1965·Experimental Cell Research·V K HOPSU, A U ARSTILA
Jul 20, 1942·The Journal of General Physiology·S HechtM H Pirenne

❮ Previous
Next ❯

Citations

Dec 15, 1996·Microscopy Research and Technique·L Vollrath, I Spiwoks-Becker
Jul 13, 2000·Microscopy Research and Technique·C W Morgans
Sep 6, 2001·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·D Lenzi, H von Gersdorff
Sep 1, 1992·Journal of Neuroscience Research·S CatsicasR J Milner
Oct 23, 1997·Protein Science : a Publication of the Protein Society·C R WangJ Deisenhofer
Dec 1, 1994·Cell and Tissue Research·P Redecker, R W Veh
Sep 1, 1993·Journal of Neurocytology·B B Boycott, J M Hopkins
Oct 1, 1996·Journal of Neurocytology·G W Balkema, R Rizkalla
Oct 1, 1996·Journal of Neurocytology·M Nachman-Clewner, E Townes-Anderson
Jan 1, 1996·Journal of Molecular Neuroscience : MN·N Liu, N G Cooper
Jan 16, 2014·Cognitive Neurodynamics·Loc Bui, Mladen I Glavinović
Oct 24, 2007·Molecular Neurobiology·Wallace B Thoreson
Mar 3, 2009·Molecular Neurobiology·George Zanazzi, Gary Matthews
Jan 15, 1992·Biological Psychiatry·W G HonerP Davies
Aug 20, 1993·Brain Research. Developmental Brain Research·M BergmannM Gratzl
Jul 15, 1994·Brain Research. Developmental Brain Research·J P KapfhammerM E Schwab
Jun 1, 1991·Current Opinion in Neurobiology·M Matteoli, P De Camilli
Aug 1, 1991·Current Opinion in Neurobiology·D R Copenhagen
Jan 1, 1993·Cell·S H DeVries, D A Baylor
Feb 13, 2001·Journal of Neuroscience Methods·M SchollA Offenhäusser
Nov 14, 1997·Brain Research. Developmental Brain Research·N K DhingraT R Raju
Mar 3, 1998·Progress in Neurobiology·P S GuthP Valli
Apr 25, 2000·Progress in Neurobiology·C Redies
Jan 29, 2011·Visual Neuroscience·Qun-Fang Wan, Ruth Heidelberger
Aug 18, 2000·Immunology and Cell Biology·C W Morgans
Nov 17, 1999·The European Journal of Neuroscience·J H BrandstätterH Wässle

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.