Synaptic alterations in the medial geniculate bodies and the inferior colliculi in Alzheimer's disease: a Golgi and electron microscope study

Acta Oto-laryngologica
Stavros J BaloyannisLeonidas S Manolides

Abstract

The neuronal loss and the alteration of the synapses in the medial geniculate bodies and the inferior colliculi may be involved in the impairment of communication and symbolic sound perception, which is noticed even in the early stages of Alzheimer's disease. Alzheimer's disease (AD) is a neurodegenerative disorder, causing a progressive decline of intellectual faculties, gradual impairment of behavior and social performance, impairment of communication and speech eloquence, and various neurological manifestations. We attempted to figure out the synaptic alterations in the medial geniculate bodies and the inferior colliculi in 12 early cases of Alzheimer's disease, who fulfilled the clinical, and laboratory diagnostic criteria of Alzheimer's disease. For the histological study we applied routine neuropathological techniques as well as Bodian staining and rapid Golgi method. We proceeded to electron microscopy for the ultrastructural study of synapses and dendritic spines. The morphological and morphometric analysis revealed substantial neuronal loss and synaptic alterations in the medial geniculate bodies as well as in inferior colliculi. Dendritic spines of the polyhedral and elongated cells of the medial geniculate bodies wer...Continue Reading

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Citations

Feb 16, 2011·Archives of Neurology·Frank R LinLuigi Ferrucci
Jan 23, 2013·JAMA Internal Medicine·Frank R LinUNKNOWN Health ABC Study Group
Jul 7, 2011·Neuropsychology·Frank R LinSusan M Resnick
Jul 20, 2011·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Frank R Lin
May 7, 2011·The International Journal of Neuroscience·Ioannis A MavroudisStavros J Baloyannis
Nov 30, 2016·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Yuqiu ZhengJun Liu
Jul 16, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Mark W AlbersLi I Zhang
Sep 2, 2020·Neuron·Timothy D GriffithsWilliam Sedley

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