PMID: 9450537Feb 5, 1998Paper

Synaptic and axonal remodeling of mossy fibers in the hilus and supragranular region of the dentate gyrus in kainate-treated rats

The Journal of Comparative Neurology
T P SutulaR Rod

Abstract

Seizures evoked by kainic acid and a variety of experimental methods induce sprouting of the mossy fiber pathway in the dentate gyrus. In this study, the morphological features and spatial distribution of sprouted mossy fiber axons in the dorsal dentate gyrus of kainate-treated rats were directly shown in granule cells filled in vitro with biocytin and in vivo with the anterograde lectin tracer Phaseolus vulgaris leucoagglutinin (PHAL). Sprouted axon collaterals of biocytin-filled granule cells projected from the hilus of the dentate gyrus into the supragranular layer in both transverse and longitudinal directions in kainate-treated rats but were not observed in normal rats. The sprouted axon collaterals projected into the supragranular region for 600-700 microm along the septotemporal axis. Collaterals from granule cells in the infrapyramidal blade crossed the hilus and sprouted into the supragranular layer of the suprapyramidal blade. Sprouted axon segments in the supragranular layer had more terminal boutons per unit length than the axon segments in the hilus of both normal and kainate-treated rats but did not form giant boutons, which are characteristic of mossy fiber axons in the hilus and CA3. Mossy fiber axons in the hil...Continue Reading

References

Apr 6, 1979·Anatomy and Embryology·D G Amaral
Sep 8, 1978·Brain Research·R G StrubleW B Levy
Oct 15, 1978·The Journal of Comparative Neurology·L W SwansonW M Cowan
Dec 15, 1978·The Journal of Comparative Neurology·D G Amaral
May 15, 1991·The Journal of Comparative Neurology·M P Witter, D G Amaral
Sep 20, 1991·Science·L R Squire, S Zola-Morgan
Jul 1, 1990·Journal of Neurophysiology·J D Lambert, R S Jones
Jan 1, 1990·Progress in Brain Research·D G AmaralB Claiborne
May 22, 1990·The Journal of Comparative Neurology·N IshizukaD G Amaral
Sep 1, 1989·Annals of Neurology·T SutulaL Ramirez
May 8, 1989·Neuroscience Letters·A RepresaY Ben-Ari
Aug 28, 1989·Brain Research·N C de LanerolleD D Spencer
Apr 22, 1986·The Journal of Comparative Neurology·B J ClaiborneW M Cowan
Jul 10, 1981·The Journal of Comparative Neurology·J M Wyss
Dec 1, 1983·Experimental Neurology·R BartesaghiL Sperti
Apr 1, 1993·Current Opinion in Neurobiology·D G Amaral
Jan 1, 1993·Annual Review of Neuroscience·S Zola-Morgan, L R Squire

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Citations

Nov 28, 2002·The Journal of Comparative Neurology·Helen E ScharfmanJeffrey H Goodman
Mar 12, 2008·The Journal of Cell Biology·Grzegorz M WilczynskiLeszek Kaczmarek
Jun 23, 2009·Brain Research·Sofia Díaz-CintraCharles E Ribak
Apr 15, 2008·Neurochemistry International·Zhi-Hong ChiZhan-You Wang
Oct 12, 2007·Neuroscience·F A KonopackiG M Wilczynski
Oct 17, 2006·The European Journal of Neuroscience·Céline DinocourtScott M Thompson
Feb 28, 2006·Epilepsy & Behavior : E&B·Jose E Cavazos, Devin J Cross
Sep 17, 2005·Brain Research. Molecular Brain Research·Joshua G HunsbergerSamuel S Newton
Oct 4, 2005·Epilepsy & Behavior : E&B·Suzanne B Bausch
Mar 10, 2010·NeuroImage·Teemu LaitinenOlli Gröhn
Jun 14, 2017·Journal of Neuroscience Research·Elizabeth B HutchinsonCarlo Pierpaoli
Dec 22, 2007·Toxicologic Pathology·Alok K SharmaPaul W Snyder
Mar 29, 2002·The Journal of Comparative Neurology·Paul S BuckmasterGuo Feng Zhang
Mar 6, 2003·The Journal of Comparative Neurology·José E CavazosThomas P Sutula
Jul 17, 2010·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Cayetano E Napolitano, Miguel A Orriols
Jul 30, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Marisa RobertoGeorge R Siggins
Jul 7, 1999·Nature·J O McNamara
Apr 4, 2018·Neuroscience Journal·Soichiro NakaharaTheo G M van Erp
Mar 4, 2020·International Journal of Molecular Sciences·Fiona LimanaqiFrancesco Fornai
Mar 15, 2001·Journal of Neurophysiology·J P Wuarin, F E Dudek
Mar 23, 2011·Cellular and Molecular Neurobiology·M E CorcoranJ R Moskal
May 16, 2019·Proceedings of the National Academy of Sciences of the United States of America·William D HendricksEric Schnell
Jan 12, 2001·Journal of Neurophysiology·B N Smith, F E Dudek
Aug 28, 2004·Journal of Neuropathology and Experimental Neurology·Seong Yun KimMun-Yong Lee
Sep 25, 2017·The International Journal of Neuroscience·Xiaoqian ZhangWeiyu Teng

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