Synaptic and intrinsic activation of GABAergic neurons in the cardiorespiratory brainstem network.

PloS One
Julie Frank, David Mendelowitz

Abstract

GABAergic pathways in the brainstem play an essential role in respiratory rhythmogenesis and interactions between the respiratory and cardiovascular neuronal control networks. However, little is known about the identity and function of these GABAergic inhibitory neurons and what determines their activity. In this study we have identified a population of GABAergic neurons in the ventrolateral medulla that receive increased excitatory post-synaptic potentials during inspiration, but also have spontaneous firing in the absence of synaptic input. Using transgenic mice that express GFP under the control of the Gad1 (GAD67) gene promoter, we determined that this population of GABAergic neurons is in close apposition to cardioinhibitory parasympathetic cardiac neurons in the nucleus ambiguus (NA). These neurons fire in synchronization with inspiratory activity. Although they receive excitatory glutamatergic synaptic inputs during inspiration, this excitatory neurotransmission was not altered by blocking nicotinic receptors, and many of these GABAergic neurons continue to fire after synaptic blockade. The spontaneous firing in these GABAergic neurons was not altered by the voltage-gated calcium channel blocker cadmium chloride that blo...Continue Reading

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Citations

Aug 1, 2014·Pediatric Neurology·Siddharth SrivastavaMichael Johnston
Jul 16, 2013·Respiratory Physiology & Neurobiology·Franck Kalume
Apr 15, 2015·Applied Psychophysiology and Biofeedback·Ravinder JerathKyler Harden
May 10, 2018·The Journal of Physiology·Jan Marino RamirezIbis M Agosto-Marlin

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