Synaptic and mitochondrial physiopathologic changes in the aging nervous system and the role of zinc ion homeostasis

Mechanisms of Ageing and Development
Carlo Bertoni-FreddariP Fattoretti

Abstract

Brain performances, e.g. learning and memory, decay during aging. Deterioration of synaptic junctions, as structural correlates of these key functions of the central nervous system, may play a central role in this impairment. Current research on the age-related changes of synapses is documenting that the numeric loss of contacts appears to trigger a compensatory reaction by the old CNS, i.e. the surviving junctional areas in old individuals are larger than in adult subjects. The final outcome of the balanced changes in synaptic number and size is that the overall synaptic junctional area per cubic micron of neuropil is also reduced in aging and this may account for the age-associated functional decay of CNS performances. Among the suggested determinants of synaptic deterioration in aging, a considerable number of recent studies support an early and pivotal role of the progressive decline of the mitochondrial metabolic competence, i.e. the capacity of select pools of organelles to provide adequate amounts of adenosine triphosphate. Quantitative ultrastructural studies together with cytochemistry of key enzymes of the respiratory chain (cytochrome oxidase and succinic dehydrogenase) have shown that mitochondrial dysfunctions play...Continue Reading

References

Jun 1, 1992·Pathology, Research and Practice·C Bertoni-FreddariJ Ulrich
Jan 20, 1992·Brain Research·G R ChalmersV R Edgerton
Sep 1, 1990·Brain Research. Brain Research Reviews·R K Calverley, D G Jones
Jan 1, 1990·Neurobiology of Aging·S W ScheffD A Price
Mar 1, 1989·Trends in Neurosciences·M T Wong-Riley
Sep 1, 1988·Neurobiology of Aging·L deToledo-MorrellF Morrell
Apr 1, 1985·Brain Research·A M Sirevaag, W T Greenough
Jan 1, 1985·Neurobiology of Aging·S W ScheffS T DeKosky
Jun 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·R K Carlin, P Siekevitz
Apr 19, 1984·Nature·S Y Assaf, S H Chung
Sep 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·M Nieto-SampedroC W Cotman
Jul 1, 1981·Physiological Reviews·C W CotmanE W Harris
Jan 23, 1995·Behavioural Brain Research·J R WolffM Missler
Feb 15, 1994·Microscopy Research and Technique·J Bereiter-Hahn, M Vöth
Nov 19, 1993·Brain Research·C Bertoni-FreddariJ Ulrich
Jan 1, 1996·Gerontology·C Bertoni-FreddariW Meier-Ruge
Nov 5, 1997·Annals of the New York Academy of Sciences·W A Meier-Ruge, C Bertoni-Freddari
Apr 8, 1998·Annual Review of Neuroscience·D V Buonomano, M M Merzenich
May 21, 1998·Mechanisms of Ageing and Development·P FattorettiW Meier-Ruge
Jan 23, 1999·Free Radical Biology & Medicine·M KarbowskiT Wakabayashi
Mar 2, 1999·Archives of Biochemistry and Biophysics·J WudarczykE Lenartowicz
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·S L SensiJ H Weiss
May 10, 2000·The Journal of Nutrition·C J FredericksonR B Thompson
Oct 26, 2000·Trends in Pharmacological Sciences·J H WeissJ Y Koh
Nov 9, 2000·Micron : the International Research and Review Journal for Microscopy·C Bertoni-FreddariW Meier-Ruge
Dec 15, 2000·Cell Calcium·E C ToescuA Verkhratsky
May 5, 2001·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·T Arendt
Apr 27, 2002·Micron : the International Research and Review Journal for Microscopy·Carlo Bertoni-FreddariAlessandro Ducati
Mar 4, 2003·Journal of Cellular and Molecular Medicine·T Wakabayashi
Apr 22, 2003·Journal of Neuroscience Research·Atsushi TakedaNaoto Oku
May 2, 2003·Proceedings of the National Academy of Sciences of the United States of America·Stefano L SensiJohn H Weiss
Jul 13, 2004·Annals of the New York Academy of Sciences·E C Toescu, J Xiong
Sep 18, 2004·Trends in Neurosciences·Gustavo Barja

❮ Previous
Next ❯

Citations

Jul 24, 2010·Antioxidants & Redox Signaling·Cynthia A Massaad, Eric Klann
Apr 27, 2012·Rejuvenation Research·Marta BaliettiGiorgio Aicardi
Mar 25, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sung W ChoiMartin D Brand
Mar 2, 2010·Ageing Research Reviews·Marta BaliettiPatrizia Fattoretti
Sep 29, 2009·Neurochemistry International·Anna RonowskaAndrzej Szutowicz
Oct 22, 2008·Experimental Neurology·Torrie T Jones, Gregory J Brewer
May 21, 2009·Microscopy Research and Technique·Marta BaliettiCarlo Bertoni-Freddari
May 19, 2010·Journal of Neurochemistry·Romina M UrangaJeffrey N Keller
Aug 7, 2013·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Zhen WangAijun Hao
Jul 9, 2010·Molecular and Biochemical Parasitology·Yubao WangAmos Orlofsky
Dec 15, 2007·Experimental Gerontology·Carlo Bertoni-FreddariMarta Balietti
Oct 17, 2012·Neurochemistry International·Fudong Liu, Louise D McCullough
Jan 1, 2017·Neurochemical Research·Andrzej SzutowiczJoanna Klimaszewska-Łata
Dec 1, 2015·Journal of Food and Drug Analysis·Fang LiuLiyan Zhao

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved