Synaptic and spiking dynamics underlying reward reversal in the orbitofrontal cortex

Cerebral Cortex
Gustavo Deco, Edmund T Rolls

Abstract

Cognitive and emotional flexibility involve a coordinated interaction between working memory, attention, reward expectations, and the evaluation of rewards and punishers so that behaviour can be changed if necessary. We describe a model at the integrate-and-fire neuronal level of the synaptic and spiking mechanisms which can hold an expectation of a reward rule in working memory, and can reverse the reward rule if expected rewards are not obtained. An example of a reward rule is that stimulus 1 is currently associated with reward, and stimulus 2 with punishment. The attractor-based reward rule working memory incorporates a spike-frequency synaptic adaptation mechanism which supports the neural switching between rules by being shut down by a general inhibitory input produced by punishment, so that when the attractor starts up again is in the opposite state. The mechanism can implement one-trial reward reversal, which is a property of orbitofrontal cortex neurons. We show how this reward rule input can operate in a biased competition way to influence which one of two stimuli is currently associated with reward and which with punishment, and to map the stimuli correctly to the reward or punishment representations, providing a basi...Continue Reading

Citations

Sep 15, 2005·Experimental Brain Research·Gustavo DecoJoaquín Fuster
Nov 13, 2008·Cognitive Neurodynamics·Anja StemmeAstrid Busch
Feb 14, 2006·Psychological Medicine·Monique ErnstMichael Hardin
Jul 16, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Michael J Frank, John A Fossella
Jul 4, 2006·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Edmund T Rolls
Oct 9, 2007·Journal of Cognitive Neuroscience·J P LarssonGustavo Deco
Nov 17, 2007·Journal of Cognitive Neuroscience·Marco LohGustavo Deco
Jan 24, 2013·Neural Computation·Andrea Soltoggio, Jochen J Steil
May 6, 2010·PLoS Computational Biology·Ariel ZylberbergMariano Sigman
Jan 19, 2016·Frontiers in Psychology·Ian Clark, Guillaume Dumas
Dec 6, 2005·The European Journal of Neuroscience·Marco Loh, Gustavo Deco
May 12, 2004·Brain and Cognition·Edmund T Rolls
Sep 24, 2014·Cerebral Cortex·T ShinerR J Dolan
May 6, 2016·Annual Review of Nutrition·Edmund T Rolls
Aug 28, 2012·Neuron·Domenica BuetiEmiliano Macaluso
Nov 1, 2005·Progress in Neurobiology·Gustavo Deco, Edmund T Rolls
Oct 31, 2006·Journal of Physiology, Paris·Edmund T Rolls, Simon M Stringer
Sep 29, 2017·Neural Computation·Samuel J Gershman
May 19, 2007·Journal of Computational Neuroscience·Anja StemmeAstrid Busch
Dec 6, 2005·Experimental Brain Research·Edmund T RollsKazuo Inoue
Mar 9, 2007·The Proceedings of the Nutrition Society·Edmund T Rolls
Jun 5, 2013·Cognitive Neurodynamics·Maurizio Mattia, Maria V Sanchez-Vives
Oct 2, 2019·Nature Reviews. Neuroscience·Samuel J Gershman, Naoshige Uchida
Jul 12, 2012·The European Journal of Neuroscience·Edmund T RollsGustavo Deco
Dec 29, 2020·Brain Communications·Edmund T RollsJianfeng Feng
May 6, 2014·Neuropsychologia·Seth A HerdNaomi P Friedman
Apr 9, 2021·Social Cognitive and Affective Neuroscience·Edmund T Rolls
Jul 24, 2021·Cerebral Cortex Communications·Edmund T RollsJianfeng Feng

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