Abstract
During development of the nervous system following axon pathfinding, synaptic connections are established between neurons. Specific cell adhesion molecules (CAMs) accumulate at pre- and postsynaptic sites and trigger synaptic differentiation through interactions with intra- and extracellular scaffolds. These interactions are important to align pre- and postsynaptic transduction machineries and to couple the sites of cell-to-cell adhesion to the cytoskeleton and signaling complexes necessary to accumulate and recycle presynaptic vesicles, components of exo- and endocytic zones, and postsynaptic receptors. In mature brains, CAMs contribute to regulation of synaptic efficacy and plasticity, partially via direct interactions with postsynaptic neurotransmitter receptors and presynaptic voltage-gated ion channels. This chapter is to highlight the major classes of synaptic CAMs, their multiple functions, and the multistage concerted interactions between different CAMs and other components of synapses.
Citations
Jun 27, 2013·Proceedings of the National Academy of Sciences of the United States of America·Linqi WangXiaorong Lin
Jan 5, 2014·PloS One·Sandra Berger-MüllerTakashi Suzuki
Aug 20, 2014·Genetic Testing and Molecular Biomarkers·Jishui ZhangFang Fang
Nov 9, 2015·Neurochemical Research·Ivan L SalazarCarlos B Duarte
Apr 22, 2015·Neurodegenerative Disease Management·Ikhlas A Sindi, Peter R Dodd
Nov 5, 2014·Frontiers in Neuroanatomy·Aaron D LevyAnthony J Koleske
Sep 7, 2016·Molecular and Cellular Neurosciences·Jeannine A Frei, Esther T Stoeckli
Jul 6, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Philip Washbourne
Jun 23, 2016·Journal of Neurochemistry·Katarzyna LepetaConstanze Seidenbecher
Jul 4, 2013·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Silvia BassaniMaria Passafaro
Jun 16, 2015·Nutrition & Diabetes·K GoncharovaS G Pierzynowski
Apr 24, 2014·Protein & Cell·Xiaofei YangChen Zhang
Mar 27, 2015·Journal of Neuroscience Research·Nilmini ViswaprakashVishnu Suppiramaniam
Oct 15, 2013·Journal of Neurochemistry·Leann H BrennamanPatricia F Maness
Mar 19, 2014·The European Journal of Neuroscience·Jeannine A Frei, Esther T Stoeckli
May 28, 2015·Developmental Neurobiology·Douglas R KolsonGeorge A Spirou
Oct 10, 2018·Frontiers in Cell and Developmental Biology·Adam Gorlewicz, Leszek Kaczmarek
Dec 7, 2018·Frontiers in Cellular Neuroscience·Tomoo Hirano
May 3, 2019·Scientific Reports·Uta WrackmeyerMichael Gotthardt
Jun 1, 2016·Journal of Neurochemistry·Dominique Fernandes, Ana Luísa Carvalho
Feb 20, 2015·The Journal of Experimental Biology·Arunkumar Krishnan, Helgi B Schiöth
Aug 5, 2021·The International Journal of Neuroscience·Jahanshahi MehrdadNikmahzar Emsehgol
Apr 30, 2013·Neuron·Janina BoykenJohn Jia En Chua