Synaptic changes in the striatum of schizophrenic cases: a controlled postmortem ultrastructural study

Synapse
L KungR C Roberts

Abstract

Although studies indicate abnormalities in the striatum of schizophrenic people, little information exists on the synaptic changes that may be present at the ultrastructural level. Autopsy specimens of striatal tissue from people with schizophrenia, normal controls, and psychiatric controls were obtained from the Maryland Brain Collection. Several abnormalities were noted in the schizophrenic group that were not present in the normal or psychiatric controls. In schizophrenic tissue, the density and/or proportion of symmetric synaptic profiles, particularly those ending on spines, were lower in the caudate vs. the putamen, implying an imbalance in inhibitory synaptic transmission between these two structures. The density of perforated synaptic profiles, cortical afferents thought to be involved in synaptic turnover and cognition, was lower in the striatum of the schizophrenic group compared to the control groups. The density of axodendritic synaptic profiles, particularly of the asymmetric type, was decreased in the caudate, but not the putamen, of a subset of schizophrenic cases that were nondyskinetic and off drugs (NDODS). The proportion of asymmetric axospinous synaptic profiles was elevated in the caudate of the NDODS cases...Continue Reading

References

Sep 17, 1976·Brain Research·M DiFigliaT Pasik
Jun 10, 1977·Brain Research·P L McGeerK Singh
Aug 1, 1992·The American Journal of Psychiatry·J M CleghornE S Garnett
Dec 1, 1992·Archives of General Psychiatry·M S BuchsbaumP A Jerabek
Jan 1, 1992·Neuroscience and Behavioral Physiology·E A Aganova, N A Uranova
Aug 1, 1990·The Journal of Comparative Neurology·H Kita, S T Kitai
Oct 1, 1991·Archives of General Psychiatry·T L JerniganD L Braff
Feb 1, 1991·The British Journal of Psychiatry : the Journal of Mental Science·A H YoungD Kean
Sep 1, 1990·The Journal of Comparative Neurology·B Lavoie, A Parent
Jan 1, 1985·Progress in Neuro-psychopharmacology & Biological Psychiatry·J E KleinmanC J Gillin
May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·Y GeinismanL deToledo-Morrell
Jun 1, 1987·Neurochemical Pathology·M F BealJ B Martin
Apr 1, 1988·Psychiatry Research·S M ResnickM Reivich
Jan 1, 1988·Schizophrenia Bulletin·J E KleinmanG E Jaskiw
May 1, 1988·Biological Psychiatry·J Wortis
May 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·Y GeinismanF Morrell
Jul 1, 1987·Archives of General Psychiatry·F M Benes, E D Bird
Jan 8, 1987·The Journal of Comparative Neurology·M DiFiglia
Jan 1, 1986·Archives of General Psychiatry·F M BenesE D Bird
Mar 11, 1985·Brain Research·F M BenesV B Domesick
Apr 1, 1985·Brain Research·A M Sirevaag, W T Greenough
Aug 1, 1985·Archives of General Psychiatry·B BogertsR Schönfeldt-Bausch
Sep 30, 1971·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J M Kemp, T P Powell
Sep 30, 1971·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J M Kemp, T P Powell
Sep 30, 1971·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J M Kemp, T P Powell
Sep 22, 1969·Zeitschrift für Zellforschung und mikroskopische Anatomie·A Peters, I R Kaiserman-Abramof

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Citations

Aug 21, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Daniel Paul Eisenberg, Karen Faith Berman
Apr 5, 2005·Journal of Psychiatric Research·Sitra Tauscher-WisniewskiRobert B Zipursky
Mar 31, 2015·Schizophrenia Bulletin·Lesley A McCollumRosalinda C Roberts
Apr 24, 1999·The European Journal of Neuroscience·A Bozhilova-Pastirova, W Ovtscharoff
Sep 15, 2004·Der Nervenarzt·H Scherk, P Falkai
Jan 1, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Chiara MagriSergio Barlati
Jan 22, 2010·Journal of Neurochemistry·Emma Perez-CostasRosalinda C Roberts
Mar 5, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Matthias RothermundtVolker Arolt
Jun 14, 2019·Schizophrenia Bulletin·Amber Berdenis van BerlekomLot D de Witte
Mar 9, 2011·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Gábor Faludi, Károly Mirnics

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