DOI: 10.1101/500389Dec 19, 2018Paper

Synaptic combinatorial molecular mechanisms generate repertoires of innate and learned behavior

BioRxiv : the Preprint Server for Biology
Noboru H KomiyamaSeth G N Grant


Although molecular mechanisms underpinning specific behaviors have been described, whether there are mechanisms that orchestrate a behavioral repertoire is unknown. To test if the postsynaptic proteome of excitatory synapses could impart such a mechanism we conducted the largest genetic study of mammalian synapses yet undertaken. A repertoire of sixteen innate and learned behaviors was assessed from 290,850 measures in 55 lines of mutant mice carrying targeted mutations in the principal classes of postsynaptic proteins. Each innate and learned behavior used a different combination of proteins. These combinations were comprised of proteins that amplified or attenuated the magnitude of each behavioral response. All behaviors required proteins found in PSD95 supercomplexes. We show the vertebrate increase in proteome complexity drove an expansion in behavioral repertoires and generated susceptibility to a wide range of diseases. Our results reveal a molecular mechanism that generates a versatile and complex behavioral repertoire that is central to human behavioral disorders.

Related Concepts

Behavior Disorders
Cell Growth
Disease Susceptibility
Mice, Mutant Strains
Cell Line, Tumor
DLG4 protein, human
Genetic Studies

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