Synaptic commitment: developmentally regulated reciprocal changes in hippocampal granule cell NMDA and AMPA receptors over the lifespan.

Journal of Neurophysiology
Zhiyong YangC A Barnes

Abstract

Synaptic transmission in hippocampal field CA1 is largely N-methyl-d-aspartate receptor (NMDA(R)) dependent during the early postnatal period. It becomes increasingly mediated by alpha-amino-3-hydroxy-5-methylisoxazole-4-proprionate (AMPA) receptors until an adult ratio of AMPA to NMDA receptors is achieved. It is shown here that increases in the AMPA receptor (AMPA(R))-mediated field potential response continue over the life span of the F-344 rat at the perforant path-granule cell synapse in the dentate gyrus. In contrast, the NMDA(R)-dependent component of the response decreases with age between 1 and 27 mo, leading to an increase of AMPA(R)/NMDA(R) ratio with age. One possible explanation of this age difference is that the AMPA(R)/NMDA(R) ratio can be modified by experience. To test the idea that the changed ratio is caused by the old rats' longer lives, an intensive 10-mo period of enrichment treatment was given to a group of animals, beginning at 3 mo of age. Compared with animals housed in standard cages, the enrichment treatment did not alter the glutamatergic response ratio measured with field potential recording methods. These data provide support for the conclusion that the observed change with age is developmentally ...Continue Reading

References

Feb 1, 1979·Journal of Comparative and Physiological Psychology·C A Barnes
May 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·S M Dudek, M F Bear
Sep 1, 1991·Neurobiology of Aging·T C FosterB L McNaughton
Jan 1, 1990·Progress in Brain Research·D G AmaralB Claiborne
May 22, 1989·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·S N Davies, G L Collingridge
Jul 1, 1971·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·D Marr
Apr 1, 1995·Current Opinion in Neurobiology·L R Squire, P Alvarez
Mar 10, 1995·Science·J E Lisman, M A Idiart
Jun 1, 1994·Current Opinion in Neurobiology·M F Bear, R C Malenka
Apr 1, 1993·Hippocampus·M W Jung, B L McNaughton
Jan 7, 1993·Nature·T V Bliss, G L Collingridge
Feb 14, 1998·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·D M Burke, D G Mackay
Sep 1, 1996·Learning & Memory·C M Coussens, T J Teyler
Sep 18, 1999·Science·R C Malenka, R A Nicoll
Jun 14, 2000·Current Opinion in Neurobiology·R MalinowY Hayashi
Dec 12, 2001·Nature Neuroscience·Desiree M VillarrealBrian E Derrick
May 22, 2003·Progress in Neurobiology·Ephron S Rosenzweig, Carol A Barnes
Mar 30, 2004·Nature Neuroscience·Alanna J WattGina G Turrigiano
May 1, 2004·Proceedings of the National Academy of Sciences of the United States of America·Scott A SmallCarol A Barnes

❮ Previous
Next ❯

Citations

Jan 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Diana S Woodruff-PakRichard F Thompson
Jan 15, 2010·Trends in Neurosciences·Sara N Burke, Carol A Barnes

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.