PMID: 13654749May 20, 1959Paper

Synaptic components of cerebellar electrocortical activity evoked by various afferent pathways

The Journal of General Physiology


Electrical responses evoked in different regions of the cerebellar cortex of cat by stimulating various cerebello-petal pathways have been analyzed for their component postsynaptic potentials (p.s.p.'s). The principal analytical tools of the present work were pharmacological agents; the selective inactivator of depolarizing (excitatory) axodendritic synapses, gamma-aminobutyric acid (GABA, or C(4)); the homologous C(6) and C(8) omega-amino acids, which inactivate selectively the hyperpolarizing (inhibitory) axodendritic synapses; and the general inactivator of inhibitory synapses, strychnine. Some experiments employed the analytical possibilities of activity cycles. The potentials evoked in one cerebellar region by different exciting pathways may differ markedly in their responses to drugs or may show different types of activity cycle. Also, the potentials evoked in various cortical regions by one cerebello-petal pathway are acted upon differently by the testing drugs. These differences are believed to be due to involvement of different proportions of excitatory and inhibitory, axosomatic and axodendritic p.s.p.'s. The analyses of a number of different responses confirm an earlier conclusion, that the cerebellar cortex is relat...Continue Reading


Jan 1, 1952·Cold Spring Harbor Symposia on Quantitative Biology·H T CHANG
Aug 1, 1956·Electroencephalography and Clinical Neurophysiology·J M BROOKHART, A ZANCHETTI

❮ Previous
Next ❯


Feb 1, 1960·Electroencephalography and Clinical Neurophysiology·T G SMITH, D P PURPURA
Feb 1, 1960·Electroencephalography and Clinical Neurophysiology·D P PURPURAH GRUNDFEST
Jun 1, 1961·Electroencephalography and Clinical Neurophysiology·D P PURPURA, E M HOUSEPIAN
Aug 1, 1969·Experimental Neurology·C M Combs, A S Diab
Aug 1, 1966·Experimental Neurology·S Deura
Nov 1, 1961·Experimental Neurology·D P PURPURA, E M HOUSEPIAN
Jul 28, 1961·Annals of the New York Academy of Sciences·D P PURPURA
Sep 6, 1961·Annals of the New York Academy of Sciences·D P PURPURA
Jul 28, 1961·Annals of the New York Academy of Sciences·H GRUNDFEST
Jun 24, 1963·Annals of the New York Academy of Sciences·D P PURPURA

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.