Synaptic Connectivity between the Cortex and Claustrum Is Organized into Functional Modules.

Current Biology : CB
Zach ChiaGilad Silberberg

Abstract

The widespread reciprocal connectivity between the claustrum and the neocortex has stimulated numerous hypotheses regarding its function; all of these suggest that the claustrum acts as a hub that connects multiple cortical regions via dense reciprocal synaptic pathways. Although the connectivity between the anterior cingulate cortex (ACC) and the claustrum has been proposed as an important pathway for top-down cognitive control, little is known about the synaptic inputs that drive claustrum cells projecting to the ACC. Here, we used multi-neuron patch clamp recordings, retrograde and anterograde viral labeling, and optogenetics in mouse claustrum to investigate cortical inputs and outputs of ACC-projecting claustrum (CLA-ACC) neurons. Both ipsilateral and contralateral cortical regions were found to provide synaptic input to CLA-ACC neurons. These cortical regions were predominantly frontal and limbic regions and not primary sensorimotor regions. We show that CLA-ACC neurons receive monosynaptic input from the insular cortex, thereby revealing a potential claustrum substrate mediating the Salience Network. In contrast, sensorimotor cortical regions preferentially targeted non CLA-ACC claustrum neurons. Using dual retrograde la...Continue Reading

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Citations

Sep 26, 2020·The Journal of Comparative Neurology·Brian A MarriottJesse Jackson
Jun 1, 2021·Frontiers in Neural Circuits·Kelly L L WongGeorge J Augustine
Sep 23, 2020·Current Biology : CB·Martin GrafGeorge J Augustine
Dec 9, 2020·Current Biology : CB·Jared B SmithJesse Jackson

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