Synaptic connectivity of distinct hilar interneuron subpopulations

Journal of Neurophysiology
M Forti, H B Michelson

Abstract

Dual intracellular recordings of hilar interneurons and CA3 pyramidal cells were performed in transverse slices of guinea pig hippocampus in the presence of the convulsant compound 4-aminopyridine (4-AP) and ionotropic glutamate receptor antagonists. Under these conditions, interneurons burst fire synchronously, producing synchronized inhibitory postsynaptic potentials (sIPSPs) in pyramidal cells. Three different hilar interneuron subpopulations that contributed to the sIPSP were identified based on their projection properties and morphology. These three types were pyramidal-like stellate interneurons, spheroid interneurons, and oviform interneurons. Physiologically, pyramidal-like stellate interneurons could be differentiated from the other interneuron subpopulations because they generated short synchronized bursts of action potentials coincident with the hyperpolarizing and depolarizing gamma-aminobutyric acid-A (GABAA)-mediated inhibitory postsynaptic potentials (IPSPs) recorded in pyramidal cells. The bursts in pyramidal-like stellate cells were abolished by theGABAA-receptor blocker, bicuculline. In contrast, spheroid interneurons of the dentate-hilus (D-H) border and oviform hilar interneurons exhibited prolonged bicucull...Continue Reading

References

Dec 15, 1978·The Journal of Comparative Neurology·D G Amaral
May 15, 1992·Science·G BuzsákiK Wise
Jul 1, 1987·The Journal of Physiology·R Miles, R K Wong
May 15, 1994·The Journal of Physiology·H B Michelson, R K Wong
Jun 1, 1996·The Journal of Physiology·R D TraubJ G Jefferys
Jan 1, 1996·Hippocampus·T F Freund, G Buzsáki
Dec 1, 1996·Journal of Neurophysiology·K L Perkins, R K Wong

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Citations

Jan 19, 2017·Reviews in the Neurosciences·Mojdeh NavidhamidiNasrin Mehranfard
Jan 6, 2007·The Journal of Physiology·Li-Ying Fu, Anthony N van den Pol

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